HitPredict

Interactor 1: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Interactor 2: Q1RLN5 (Q1RLN5)
ARHGAP12 protein (Rho GTPase activating protein 12)
Gene: ARHGAP12

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	21706016
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	SH2~SH3_1, PH~SH3_1, SH3_1~SH3_1
Common GO terms	GO:0005737 - cytoplasm GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 217 Hs			1 799
+	Hs
		924686 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		RHG12_HUMAN (1-799): 0: 721: 94.44
+	Hs
		411755 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		RHG21_HUMAN (68-799): 1.01e-113: 382: 21.44
+	Hs
		557714 NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14		RHG21_HUMAN (68-799): 1.01e-113: 382: 21.44
+	Hs
		924798 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		ARAP1_HUMAN (312-797): 8.74e-69: 249: 16.98
+	Hs
		924852 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		RGAP1_HUMAN (311-791): 4.06e-69: 241: 17.66
+	Hs
		64687 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		RHG32_HUMAN (558-797): 1.49e-65: 240: 29.03
+	Hs
		200212 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		SRGP3_HUMAN (479-798): 9.45e-66: 239: 20.00
+	Hs
		924893 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		RHG35_HUMAN (551-797): 7.98e-65: 238: 28.57
+	Dm
		993184 GRAP_DROME (1-215): 5.1e-62: 194: 62.79		Q0KHR5_DROME (86-798): 1.41e-69: 252: 14.71
+	Hs
		557642 NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14		CHIO_HUMAN (331-797): 8.93e-90: 292: 18.09
+	Hs
		64641 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		RHG32_HUMAN (558-797): 1.49e-65: 240: 29.03
+	Hs
		551038 NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14		CHIN_HUMAN (375-797): 1.35e-83: 276: 18.97
+	Hs
		557775 NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14		ARAP1_HUMAN (312-797): 8.74e-69: 249: 16.98
+	Mm
		1141138 GRB2_MOUSE (1-217): 2.48e-76: 230: 99.54		BCR_MOUSE (585-772): 3.59e-25: 114: 39.27
+	Hs
		506565 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		BCR_HUMAN (585-772): 5.25e-25: 114: 39.27
+	Hs
		64651 NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14		RHG32_HUMAN (558-797): 1.49e-65: 240: 29.03
+	Hs
		337453 ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46		ABR_HUMAN (553-797): 5.92e-63: 228: 30.59
+	Hs
		506586 GRAP_HUMAN (1-213): 2.32e-66: 205: 56.74		BCR_HUMAN (585-772): 5.25e-25: 114: 39.27
+	Hs
		924831 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		RHG09_HUMAN (21-362): 3.39e-12: 72: 14.76
+	Hs
		337325 ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46		BCR_HUMAN (585-772): 5.25e-25: 114: 39.27