HitPredict

Interactor 1: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Interactor 2: LRRK1 (Q38SD2)
Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1)
Gene: LRRK1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.82	0.60	0.703

Property	Details
Experiments	20697350, 31980649, 19380743, unassigned2173, 24947832
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 217 Hs			1 2015
+	Mm
		1112541 GRB2_MOUSE (1-217): 2.48e-76: 230: 99.54		LRRK1_MOUSE (1-2015): 0: 1793: 88.49
+	Hs
		337488 ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46		LRRK1_HUMAN (1-2015): 0: 1859: 99.60
+	Hs
		66464 A8K3B6_HUMAN (2-139): 3.88e-24: 100: 36.24		LRRK2_HUMAN (47-285): 1.02e-20: 102: 11.65
+	Hs
		337490 ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46		LRRK2_HUMAN (47-285): 1.02e-20: 102: 11.65
+	Hs
		789074 ABL2_HUMAN (4-139): 9.61e-22: 94.7: 34.04		LRRK2_HUMAN (47-285): 1.02e-20: 102: 11.65
+	Hs
		789058 ABL2_HUMAN (4-139): 9.61e-22: 94.7: 34.04		M3K10_HUMAN (1247-1521): 1.17e-20: 101: 32.41