HitPredict

Interactor 1: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Interactor 2: H2B2F (Q5QNW6)
Histone H2B type 2-F (H2B-clustered histone 18)
Gene: H2BC18

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.571

Property	Details
Experiments	31980649, unassigned2173
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0070062 - extracellular exosome
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 217 Hs			1 126
+	Hs
		924820 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		H2B1M_HUMAN (1-126): 2.53e-55: 170: 95.24
+	Hs
		241496 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		H2B1K_HUMAN (1-126): 7.91e-55: 169: 97.62
+	Hs
		883010 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		H2BFS_HUMAN (1-126): 7.4e-55: 169: 96.03
+	Hs
		918279 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		H2B1C_HUMAN (1-126): 6.35e-55: 169: 98.41
+	Hs
		924770 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		H2B1H_HUMAN (1-126): 3.18e-55: 169: 99.21
+	Hs
		886077 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		H2B1D_HUMAN (1-126): 1.76e-54: 168: 97.62
+	Hs
		924819 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		H2B1N_HUMAN (1-126): 1.58e-54: 168: 97.62
+	Hs
		924821 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		H2B1L_HUMAN (1-126): 1.29e-53: 166: 96.83
+	Hs
		411752 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		H2B2F_HUMAN (1-126): 7.66e-56: 171: 100.00
+	Hs
		411835 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		H2B1M_HUMAN (1-126): 2.53e-55: 170: 95.24
+	Hs
		411664 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		H2B1C_HUMAN (1-126): 6.35e-55: 169: 98.41
+	Hs
		411813 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		H2B1H_HUMAN (1-126): 3.18e-55: 169: 99.21
+	Hs
		411656 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		H2B1D_HUMAN (1-126): 1.76e-54: 168: 97.62
+	Hs
		411834 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		H2B1N_HUMAN (1-126): 1.58e-54: 168: 97.62
+	Hs
		411836 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		H2B1L_HUMAN (1-126): 1.29e-53: 166: 96.83
+	Hs
		557845 NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14		U3KQK0_HUMAN (1-126): 1.88e-56: 174: 97.62
+	Hs
		557647 NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14		H2B1D_HUMAN (1-126): 1.76e-54: 168: 97.62
+	Hs
		557738 NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14		H2B3B_HUMAN (1-126): 8.14e-53: 164: 95.24