HitPredict

Interactor 1: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Interactor 2: RNF43 (Q68DV7)
E3 ubiquitin-protein ligase RNF43 (EC 2.3.2.27) (RING finger protein 43) (RING-type E3 ubiquitin transferase RNF43)
Gene: RNF43

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35676246
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 217 Hs			1 783
+	Mm
		610598 GRB2_MOUSE (1-217): 2.48e-76: 230: 99.54		CBL_MOUSE (272-682): 5.02e-63: 229: 14.42
+	Rn
		88774 GRB2_RAT (1-217): 6.71e-76: 229: 100.00		D3ZV15_RAT (272-682): 3.86e-60: 221: 14.66
+	Mm
		610640 GRAP_MOUSE (1-213): 7.52e-66: 204: 57.67		CBL_MOUSE (272-682): 5.02e-63: 229: 14.42
+	Hs
		610338 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		CBL_HUMAN (272-682): 4.13e-48: 185: 14.42
+	Hs
		610437 Q6ICN0_HUMAN (1-217): 3.6e-75: 227: 99.54		CBL_HUMAN (272-682): 4.13e-48: 185: 14.42
+	Mm
		411917 LCK_MOUSE (3-202): 2.89e-37: 137: 28.44		CBL_MOUSE (272-682): 5.02e-63: 229: 14.42
+	Hs
		782806 CSK_HUMAN (2-139): 3.92e-24: 100: 36.24		RN149_HUMAN (36-348): 6.63e-79: 261: 17.59
+	Mm
		610555 CSK_MOUSE (2-139): 1.12e-23: 99.4: 35.57		CBL_MOUSE (272-682): 5.02e-63: 229: 14.42
+	Mm
		610633 NCK1_MOUSE (5-145): 8.99e-23: 96.3: 33.14		CBL_MOUSE (272-682): 5.02e-63: 229: 14.42
+	Mm
		337618 ABL1_MOUSE (4-139): 4.07e-22: 95.9: 35.46		CBL_MOUSE (272-682): 5.02e-63: 229: 14.42
+	Hs
		411595 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		CBL_HUMAN (272-682): 4.13e-48: 185: 14.42
+	Mm
		610657 ITSN2_MOUSE (2-61): 2.9e-14: 73.1: 35.00		CBL_MOUSE (272-682): 5.02e-63: 229: 14.42
+	Mm
		610554 FYN_MOUSE (161-215): 4.44e-14: 72.3: 31.58		CBL_MOUSE (272-682): 5.02e-63: 229: 14.42
+	Hs
		610276 CSK_HUMAN (2-139): 3.92e-24: 100: 36.24		CBL_HUMAN (272-682): 4.13e-48: 185: 14.42
+	Hs
		557607 NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14		CBL_HUMAN (272-682): 4.13e-48: 185: 14.42
+	Hs
		337348 ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46		CBL_HUMAN (272-682): 4.13e-48: 185: 14.42
+	Hs
		610281 ABL2_HUMAN (4-139): 9.61e-22: 94.7: 34.04		CBL_HUMAN (272-682): 4.13e-48: 185: 14.42
+	Hs
		69201 A9UF07_HUMAN (4-139): 1.63e-21: 94: 35.46		CBL_HUMAN (272-682): 4.13e-48: 185: 14.42
+	Hs
		610517 ITSN2_HUMAN (2-61): 5.91e-15: 75: 36.67		CBL_HUMAN (272-682): 4.13e-48: 185: 14.42
+	Hs
		548639 VAV_HUMAN (2-60): 8.95e-15: 74.6: 42.37		CBL_HUMAN (272-682): 4.13e-48: 185: 14.42