HitPredict

Interactor 1: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Interactor 2: RHG17 (Q68EM7)
Rho GTPase-activating protein 17 (Rho-type GTPase-activating protein 17) (RhoGAP interacting with CIP4 homologs protein 1) (RICH-1)
Gene: ARHGAP17

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	11431473
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0007165 - signal transduction GO:0017124 - SH3 domain binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 217 Hs			1 881
+	Hs
		411763 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		RHG17_HUMAN (1-881): 4.48e-144: 450: 100.00
+	Hs
		337492 ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46		RHG17_HUMAN (1-881): 4.48e-144: 450: 100.00
+	Hs
		200212 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		SRGP3_HUMAN (13-738): 1.18e-76: 272: 15.58
+	Hs
		924893 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		RHG35_HUMAN (79-472): 1.53e-65: 241: 20.10
+	Hs
		924608 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		Q1RLN5_HUMAN (53-427): 1.31e-64: 234: 17.90
+	Hs
		924686 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		RHG12_HUMAN (53-427): 1.04e-63: 232: 17.90
+	Hs
		411755 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		RHG21_HUMAN (10-685): 1.4e-69: 254: 16.46
+	Mm
		337622 ABL1_MOUSE (4-139): 4.07e-22: 95.9: 35.46		3BP1_MOUSE (1-618): 1.8e-83: 284: 38.35
+	Hs
		557714 NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14		RHG21_HUMAN (10-685): 1.4e-69: 254: 16.46
+	Hs
		337453 ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46		ABR_HUMAN (1-412): 3.62e-71: 253: 19.17
+	Hs
		557642 NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14		CHIO_HUMAN (231-442): 5.78e-65: 227: 25.12
+	Hs
		551038 NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14		CHIN_HUMAN (97-426): 2.7e-64: 225: 16.91
+	Hs
		64687 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		RHG32_HUMAN (250-462): 7.37e-18: 91.3: 29.41
+	Mm
		1141138 GRB2_MOUSE (1-217): 2.48e-76: 230: 99.54		BCR_MOUSE (250-408): 6.8e-17: 88.2: 33.54
+	Hs
		69699 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		B1AHC3_HUMAN (250-409): 9.2e-17: 86.7: 33.54
+	Hs
		506565 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		BCR_HUMAN (250-408): 2.36e-16: 86.3: 33.54
+	Hs
		506586 GRAP_HUMAN (1-213): 2.32e-66: 205: 56.74		BCR_HUMAN (250-408): 2.36e-16: 86.3: 33.54
+	Hs
		64641 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		RHG32_HUMAN (250-462): 7.37e-18: 91.3: 29.41
+	Hs
		64651 NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14		RHG32_HUMAN (250-462): 7.37e-18: 91.3: 29.41
+	Hs
		337325 ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46		BCR_HUMAN (250-408): 2.36e-16: 86.3: 33.54