HitPredict

Interactor 1: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Interactor 2: CYTSA (Q69YQ0)
Cytospin-A (Renal carcinoma antigen NY-REN-22) (Sperm antigen with calponin homology and coiled-coil domains 1-like) (SPECC1-like protein)
Gene: SPECC1L

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	12577067
Identification Methods	pull down
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0030036 - actin cytoskeleton organization
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 217 Hs			1 1117
+	Hs
		924622 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		CYTSB_HUMAN (167-1117): 3.95e-60: 226: 38.76
+	Hs
		521521 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		ACTN1_HUMAN (1009-1116): 3.96e-50: 194: 42.20
+	Hs
		211557 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		ACTN4_HUMAN (1009-1116): 6.66e-48: 187: 41.28
+	Hs
		724756 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		MYH9_HUMAN (206-1087): 3.64e-34: 144: 11.77
+	Hs
		725134 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		MYH10_HUMAN (213-1075): 1.21e-33: 143: 10.62
+	Hs
		728465 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		MYH11_HUMAN (342-1028): 7.19e-25: 114: 9.72
+	Hs
		548722 VAV_HUMAN (2-60): 8.95e-15: 74.6: 42.37		CYTSA_HUMAN (1-1117): 1.12e-71: 262: 100.00
+	Hs
		1078836 ITSN1_HUMAN (137-216): 1.36e-12: 68.1: 25.00		CYTSB_HUMAN (167-1117): 3.95e-60: 226: 38.76
+	Hs
		993249 PTK6_HUMAN (4-141): 7.14e-23: 97.1: 38.93		ACTN3_HUMAN (1009-1115): 7.86e-51: 196: 40.74
+	Hs
		433808 LYN_HUMAN (129-215): 1.44e-11: 65: 22.47		CYTSB_HUMAN (167-1117): 3.95e-60: 226: 38.76
+	Ce
		110517 SEM5_CAEEL (3-69): 6.24e-14: 70: 28.36		H2L2C8_CAEEL (1009-1116): 1.45e-49: 192: 43.12
+	Hs
		521454 SRC_HUMAN (161-215): 3.76e-11: 63.8: 31.58		ACTN1_HUMAN (1009-1116): 3.96e-50: 194: 42.20
+	Ce
		666217 SEM5_CAEEL (3-69): 6.24e-14: 70: 28.36		Q23158_CAEEL (1009-1116): 1.02e-46: 184: 40.37
+	Hs
		211480 SRC_HUMAN (161-215): 3.76e-11: 63.8: 31.58		ACTN4_HUMAN (1009-1116): 6.66e-48: 187: 41.28
+	Hs
		412058 FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58		MYH9_HUMAN (206-1087): 3.64e-34: 144: 11.77
+	Hs
		433889 LYN_HUMAN (129-215): 1.44e-11: 65: 22.47		MILK1_HUMAN (1011-1115): 2.96e-36: 150: 41.51
+	Hs
		111443 J3QRU1_HUMAN (52-215): 3.95e-13: 69.6: 14.29		MYH9_HUMAN (206-1087): 3.64e-34: 144: 11.77
+	Hs
		433272 YES_HUMAN (59-215): 4.17e-13: 69.2: 14.91		MYH9_HUMAN (206-1087): 3.64e-34: 144: 11.77
+	Hs
		433620 LYN_HUMAN (129-215): 1.44e-11: 65: 22.47		MYH9_HUMAN (206-1087): 3.64e-34: 144: 11.77
+	Hs
		523231 SRC_HUMAN (161-215): 3.76e-11: 63.8: 31.58		MYH4_HUMAN (5-608): 1.24e-21: 104: 9.44