HitPredict

Interactor 1: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Interactor 2: SHC4 (Q6S5L8)
SHC-transforming protein 4 (Rai-like protein) (RaLP) (SHC-transforming protein D) (hShcD) (Src homology 2 domain-containing-transforming protein C4) (SH2 domain protein C4)
Gene: SHC4

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	24430869, 28213521
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	SH2~SH2, SH2~SH3_1
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 217 Hs			1 630
+	Mm
		957235 GRB2_MOUSE (1-217): 2.48e-76: 230: 99.54		SHC1_MOUSE (26-620): 4.38e-150: 447: 46.55
+	Hs
		666057 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		SHC1_HUMAN (26-620): 6.45e-150: 447: 45.40
+	Hs
		666104 GRAP_HUMAN (1-213): 2.32e-66: 205: 56.74		SHC1_HUMAN (26-620): 6.45e-150: 447: 45.40
+	Rn
		924995 GRB2_RAT (1-217): 6.71e-76: 229: 100.00		SHC1_RAT (148-620): 1.16e-130: 394: 49.38
+	Hs
		924476 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		SHC2_HUMAN (81-620): 1.11e-123: 379: 38.57
+	Hs
		666186 VAV3_HUMAN (1-212): 1.16e-43: 157: 22.00		SHC1_HUMAN (26-620): 6.45e-150: 447: 45.40
+	Dm
		993194 GRAP_DROME (1-215): 5.1e-62: 194: 62.79		Q9V3C8_DROME (159-624): 1.61e-94: 298: 32.83
+	Hs
		145977 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		SH2B2_HUMAN (339-622): 5.86e-49: 182: 19.80
+	Hs
		924659 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		SH2D5_HUMAN (262-613): 1.25e-50: 182: 15.15
+	Hs
		522887 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		SRC_HUMAN (385-628): 4.11e-44: 167: 14.77
+	Hs
		924594 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		SHB_HUMAN (356-617): 5.99e-44: 166: 20.73
+	Hs
		562638 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		PLCG2_HUMAN (269-630): 5.78e-40: 159: 13.88
+	Mm
		1141166 GRB2_MOUSE (1-217): 2.48e-76: 230: 99.54		SH2B2_MOUSE (340-618): 1.18e-39: 155: 17.75
+	Hs
		557655 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		NCK1_HUMAN (425-615): 6.64e-40: 151: 17.35
+	Mm
		643091 GRB2_MOUSE (1-217): 2.48e-76: 230: 99.54		P85A_MOUSE (506-622): 3.58e-20: 97.1: 24.19
+	Hs
		655306 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		P85A_HUMAN (506-622): 3.58e-20: 97.1: 24.19
+	Hs
		924447 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		GRB2_HUMAN (520-616): 5.11e-14: 73.4: 30.48
+	Dm
		665777 GRAP_DROME (1-215): 5.1e-62: 194: 62.79		CSW_DROME (524-616): 2.51e-15: 81.9: 34.02
+	Hs
		655500 VAV3_HUMAN (1-212): 1.16e-43: 157: 22.00		P85A_HUMAN (506-622): 3.58e-20: 97.1: 24.19
+	Hs
		924938 VAV3_HUMAN (1-212): 1.16e-43: 157: 22.00		GRB2_HUMAN (520-616): 5.11e-14: 73.4: 30.48