HitPredict

Interactor 1: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Interactor 2: MPRIP (Q6WCQ1)
Myosin phosphatase Rho-interacting protein (M-RIP) (Rho-interacting protein 3) (RIP3) (p116Rip)
Gene: MPRIP

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	12577067
Identification Methods	pull down
Interaction Type	association

Property	Details
Interacting Pfam domains	PH~SH3_1
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 217 Hs			1 1025
+	Hs
		411772 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		MPRIP_HUMAN (1-1025): 9.29e-127: 412: 100.00
+	Hs
		924640 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		PKHA7_HUMAN (336-980): 5.04e-41: 166: 13.51
+	Hs
		411800 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		DLG5_HUMAN (647-1019): 8.88e-54: 207: 21.61
+	Hs
		724756 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		MYH9_HUMAN (540-1015): 1.52e-17: 90.5: 9.66
+	Hs
		725134 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		MYH10_HUMAN (534-1014): 3.94e-16: 85.9: 9.18
+	Hs
		728465 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		MYH11_HUMAN (124-786): 1.25e-12: 74.7: 11.57
+	Hs
		557746 NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14		DLG5_HUMAN (647-1019): 8.88e-54: 207: 21.61
+	Hs
		411764 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		PKHA7_HUMAN (336-980): 5.04e-41: 166: 13.51
+	Hs
		924586 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		PLEC_HUMAN (499-978): 3.1e-11: 70.1: 14.96
+	Hs
		924666 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		MYH14_HUMAN (595-972): 3.69e-09: 63.1: 14.89
+	Hs
		411861 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		PKHA5_HUMAN (318-1019): 7.56e-36: 149: 13.24
+	Hs
		411897 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		PKHA6_HUMAN (356-581): 1.69e-31: 135: 24.49
+	Hs
		433388 YES_HUMAN (59-215): 4.17e-13: 69.2: 14.91		PKHA7_HUMAN (336-980): 5.04e-41: 166: 13.51
+	Hs
		412058 FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58		MYH9_HUMAN (540-1015): 1.52e-17: 90.5: 9.66
+	Hs
		111443 J3QRU1_HUMAN (52-215): 3.95e-13: 69.6: 14.29		MYH9_HUMAN (540-1015): 1.52e-17: 90.5: 9.66
+	Hs
		433272 YES_HUMAN (59-215): 4.17e-13: 69.2: 14.91		MYH9_HUMAN (540-1015): 1.52e-17: 90.5: 9.66
+	Hs
		433620 LYN_HUMAN (129-215): 1.44e-11: 65: 22.47		MYH9_HUMAN (540-1015): 1.52e-17: 90.5: 9.66
+	Hs
		1068630 Q96D37_HUMAN (2-60): 8.82e-15: 74.6: 42.37		PLEC_HUMAN (499-978): 3.1e-11: 70.1: 14.96
+	Hs
		548710 VAV_HUMAN (2-60): 8.95e-15: 74.6: 42.37		PLEC_HUMAN (499-978): 3.1e-11: 70.1: 14.96
+	Hs
		1078856 ITSN1_HUMAN (137-216): 1.36e-12: 68.1: 25.00		MYH14_HUMAN (595-972): 3.69e-09: 63.1: 14.89