HitPredict

Interactor 1: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Interactor 2: BCAP (Q6ZUJ8)
Phosphoinositide 3-kinase adapter protein 1 (B-cell adapter for phosphoinositide 3-kinase) (B-cell phosphoinositide 3-kinase adapter protein 1)
Gene: PIK3AP1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.89	0.60	0.733

Property	Details
Experiments	28514442, 31980649, 33961781, 21706016, 21988832, unassigned2173
Identification Methods	affinity chromatography technology, two hybrid, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 217 Hs			1 805
+	Mm
		1141163 GRB2_MOUSE (1-217): 2.48e-76: 230: 99.54		BCAP_MOUSE (1-805): 0: 1310: 84.36
+	Hs
		557721 NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14		BCAP_HUMAN (1-805): 0: 1344: 100.00
+	Hs
		1172834 ITSN2_HUMAN (2-61): 5.91e-15: 75: 36.67		BCAP_HUMAN (1-805): 0: 1344: 100.00
+	Hs
		1078849 ITSN1_HUMAN (137-216): 1.36e-12: 68.1: 25.00		BCAP_HUMAN (1-805): 0: 1344: 100.00
+	Hs
		433844 LYN_HUMAN (129-215): 1.44e-11: 65: 22.47		BCAP_HUMAN (1-805): 0: 1344: 100.00
+	Mm
		1307853 NCK1_MOUSE (5-145): 8.99e-23: 96.3: 33.14		BCAP_MOUSE (1-805): 0: 1310: 84.36
+	Mm
		1322290 ITSN1_MOUSE (137-216): 1.77e-12: 67.7: 25.00		BCAP_MOUSE (1-805): 0: 1310: 84.36
+	Hs
		433898 LYN_HUMAN (129-215): 1.44e-11: 65: 22.47		BANK1_HUMAN (11-665): 0: 665: 26.73