HitPredict

Interactor 1: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Interactor 2: DOK3 (Q7L591)
Docking protein 3 (Downstream of tyrosine kinase 3)
Gene: DOK3

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.571

Property	Details
Experiments	19380743, 16436051
Identification Methods	affinity chromatography technology, coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0007265 - Ras protein signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 217 Hs			1 496
+	Mm
		1141171 GRB2_MOUSE (1-217): 2.48e-76: 230: 99.54		DOK3_MOUSE (57-496): 1.2e-152: 444: 77.70
+	Mm
		956520 GRB2_MOUSE (1-217): 2.48e-76: 230: 99.54		DOK1_MOUSE (60-491): 4.19e-125: 375: 30.19
+	Hs
		924816 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		DOK1_HUMAN (60-491): 1.13e-123: 371: 29.92
+	Hs
		151763 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		IRS4_HUMAN (65-427): 3e-89: 298: 15.90
+	Hs
		724527 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		IRS1_HUMAN (65-494): 2.85e-88: 296: 15.58
+	Rn
		724631 GRB2_RAT (1-217): 6.71e-76: 229: 100.00		IRS1_RAT (65-494): 4.24e-88: 295: 15.32
+	Mm
		724599 GRB2_MOUSE (1-217): 2.48e-76: 230: 99.54		IRS1_MOUSE (65-494): 2.12e-87: 293: 15.32
+	Mm
		946348 GRB2_MOUSE (1-217): 2.48e-76: 230: 99.54		IRS2_MOUSE (65-452): 6.66e-78: 267: 13.48
+	Rn
		94388 GRB2_RAT (1-217): 6.71e-76: 229: 100.00		F1MAL5_RAT (65-452): 1.56e-76: 263: 13.71
+	Hs
		924983 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		IRS2_HUMAN (65-452): 3.56e-75: 259: 13.38
+	Mm
		782845 CSK_MOUSE (2-139): 1.12e-23: 99.4: 35.57		DOK1_MOUSE (60-491): 4.19e-125: 375: 30.19
+	Hs
		924725 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		FRS2_HUMAN (198-491): 2.68e-66: 224: 19.81
+	Rn
		88884 GRB2_RAT (1-217): 6.71e-76: 229: 100.00		D4A244_RAT (198-490): 3.9e-64: 218: 19.88
+	Mm
		1141149 GRB2_MOUSE (1-217): 2.48e-76: 230: 99.54		FRS2_MOUSE (198-490): 2.26e-62: 213: 19.57
+	Hs
		151689 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		IRS4_HUMAN (65-427): 3e-89: 298: 15.90
+	Hs
		235035 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		DOK2_HUMAN (61-455): 2.1e-95: 296: 34.04
+	Dm
		993227 GRAP_DROME (1-215): 5.1e-62: 194: 62.79		IRS1_DROME (85-407): 4.7e-68: 237: 14.57
+	Hs
		235051 CSK_HUMAN (2-139): 3.92e-24: 100: 36.24		DOK2_HUMAN (61-455): 2.1e-95: 296: 34.04
+	Mm
		250951 CSK_MOUSE (2-139): 1.12e-23: 99.4: 35.57		DOK2_MOUSE (61-455): 8.61e-90: 282: 31.05
+	Hs
		411805 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		FRS2_HUMAN (198-491): 2.68e-66: 224: 19.81