HitPredict

Interactor 1: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Interactor 2: CLNK (Q7Z7G1)
Cytokine-dependent hematopoietic cell linker (Mast cell immunoreceptor signal transducer)
Gene: CLNK

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.55	1.00	0.743

Property	Details
Experiments	25814554, unassigned1126
Identification Methods	two hybrid, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	SH2~SH2, SH2~SH3_1
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 217 Hs			1 428
+	Rn
		924995 GRB2_RAT (1-217): 6.71e-76: 229: 100.00		SHC1_RAT (115-405): 8.38e-70: 229: 14.24
+	Mm
		1141127 GRB2_MOUSE (1-217): 2.48e-76: 230: 99.54		LCP2_MOUSE (81-420): 5.35e-68: 226: 26.72
+	Mm
		222321 GRB2_MOUSE (1-217): 2.48e-76: 230: 99.54		O54737_MOUSE (66-408): 6.16e-65: 218: 15.57
+	Hs
		924476 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		SHC2_HUMAN (115-405): 6.29e-64: 217: 15.59
+	Hs
		924727 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		BLNK_HUMAN (61-417): 1.5e-64: 216: 22.70
+	Mm
		957235 GRB2_MOUSE (1-217): 2.48e-76: 230: 99.54		SHC1_MOUSE (115-405): 5.6e-63: 214: 14.57
+	Hs
		924534 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		LCP2_HUMAN (58-421): 5.56e-63: 213: 24.46
+	Hs
		666057 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		SHC1_HUMAN (115-405): 5.33e-60: 207: 14.24
+	Hs
		924646 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		SHC4_HUMAN (115-410): 5.83e-56: 197: 14.66
+	Hs
		924890 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		SH2B1_HUMAN (252-405): 2.99e-27: 116: 20.24
+	Hs
		145977 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		SH2B2_HUMAN (115-411): 9.73e-26: 111: 15.23
+	Mm
		1141166 GRB2_MOUSE (1-217): 2.48e-76: 230: 99.54		SH2B2_MOUSE (115-411): 6.26e-23: 103: 13.62
+	Hs
		924960 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		SH2B3_HUMAN (46-418): 3.49e-21: 97.8: 13.10
+	Hs
		562638 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		PLCG2_HUMAN (270-420): 3.64e-17: 86.2: 16.88
+	Mm
		1141132 GRB2_MOUSE (1-217): 2.48e-76: 230: 99.54		PLCG1_MOUSE (292-397): 3.99e-16: 83.1: 25.42
+	Rn
		499159 GRB2_RAT (1-217): 6.71e-76: 229: 100.00		PLCG1_RAT (292-397): 2.21e-16: 83.9: 24.58
+	Hs
		580972 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		PLCG1_HUMAN (292-397): 7.5e-16: 82: 25.42
+	Mm
		719305 GRB2_MOUSE (1-217): 2.48e-76: 230: 99.54		PTN11_MOUSE (304-420): 2.88e-15: 79.7: 17.95
+	Rn
		783504 GRB2_RAT (1-217): 6.71e-76: 229: 100.00		PTN11_RAT (304-420): 2.88e-15: 79.7: 17.95
+	Hs
		924502 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		PTN11_HUMAN (304-420): 2.88e-15: 79.7: 17.95