HitPredict

Interactor 1: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Interactor 2: NEK8 (Q86SG6)
Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never in mitosis A-related kinase 8) (NimA-related protein kinase 8) (Nima-related protein kinase 12a)
Gene: NEK8

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	17474147
Identification Methods	peptide array
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 217 Hs			1 692
+	Hs
		557728 NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14		NEK8_HUMAN (1-692): 0: 727: 100.00
+	Hs
		337497 ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46		NEK8_HUMAN (1-692): 0: 727: 100.00
+	Hs
		412245 FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58		NEK8_HUMAN (1-692): 0: 727: 100.00
+	Hs
		411606 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		MARK3_HUMAN (3-436): 2.69e-134: 414: 22.60
+	Hs
		433589 LYN_HUMAN (129-215): 1.44e-11: 65: 22.47		MARK3_HUMAN (3-436): 2.69e-134: 414: 22.60
+	Hs
		433949 LYN_HUMAN (129-215): 1.44e-11: 65: 22.47		MARK4_HUMAN (3-436): 6.8e-128: 398: 22.97
+	Hs
		433348 YES_HUMAN (59-215): 4.17e-13: 69.2: 14.91		KCC2G_HUMAN (2-401): 7.59e-121: 373: 23.80
+	Hs
		411994 FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58		KAPCA_HUMAN (1-308): 1.8e-119: 362: 25.48
+	Hs
		412014 FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58		KAPCB_HUMAN (1-308): 3.33e-119: 361: 26.43
+	Hs
		433609 LYN_HUMAN (129-215): 1.44e-11: 65: 22.47		AKT2_HUMAN (1-313): 7.99e-120: 368: 25.94
+	Dm
		993223 GRAP_DROME (1-215): 5.1e-62: 194: 62.79		Q9W3N8_DROME (1-265): 2.97e-41: 162: 34.67
+	Hs
		851378 VAV2_HUMAN (3-56): 4.83e-11: 63.5: 38.18		NEK3_HUMAN (1-260): 3.03e-53: 193: 36.78