HitPredict

Interactor 1: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Interactor 2: LUZP1 (Q86V48)
Leucine zipper protein 1
Gene: LUZP1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	12577067
Identification Methods	pull down
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 217 Hs			1 1076
+	Hs
		924736 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		MY18A_HUMAN (4-516): 2.88e-29: 129: 11.91
+	Hs
		725134 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		MYH10_HUMAN (2-451): 8.79e-21: 101: 14.79
+	Hs
		728465 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		MYH11_HUMAN (259-776): 1.43e-16: 87.4: 10.15
+	Hs
		724756 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		MYH9_HUMAN (385-763): 9.36e-12: 71.6: 8.83
+	Hs
		924586 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		PLEC_HUMAN (35-503): 1.33e-11: 71.4: 16.50
+	Hs
		411581 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		DESP_HUMAN (110-643): 4.72e-23: 109: 9.89
+	Hs
		411908 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		MRCKB_HUMAN (1-350): 9.24e-20: 97.9: 15.32
+	Hs
		411758 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		MRCKA_HUMAN (1-362): 2.6e-17: 90.2: 17.96
+	Hs
		551599 NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14		DESP_HUMAN (110-643): 4.72e-23: 109: 9.89
+	Hs
		411743 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		GRDN_HUMAN (10-513): 1.42e-09: 64.9: 17.82
+	Hs
		412287 FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58		MY18A_HUMAN (4-516): 2.88e-29: 129: 11.91
+	Hs
		411983 FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58		DESP_HUMAN (110-643): 4.72e-23: 109: 9.89
+	Hs
		433558 LYN_HUMAN (129-215): 1.44e-11: 65: 22.47		DESP_HUMAN (110-643): 4.72e-23: 109: 9.89
+	Hs
		1068630 Q96D37_HUMAN (2-60): 8.82e-15: 74.6: 42.37		PLEC_HUMAN (35-503): 1.33e-11: 71.4: 16.50
+	Hs
		548710 VAV_HUMAN (2-60): 8.95e-15: 74.6: 42.37		PLEC_HUMAN (35-503): 1.33e-11: 71.4: 16.50
+	Hs
		412058 FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58		MYH9_HUMAN (385-763): 9.36e-12: 71.6: 8.83
+	Hs
		111443 J3QRU1_HUMAN (52-215): 3.95e-13: 69.6: 14.29		MYH9_HUMAN (385-763): 9.36e-12: 71.6: 8.83
+	Hs
		433272 YES_HUMAN (59-215): 4.17e-13: 69.2: 14.91		MYH9_HUMAN (385-763): 9.36e-12: 71.6: 8.83
+	Hs
		259644 ITSN1_HUMAN (137-216): 1.36e-12: 68.1: 25.00		LIPA2_HUMAN (25-401): 7.76e-11: 68.7: 17.19
+	Hs
		433620 LYN_HUMAN (129-215): 1.44e-11: 65: 22.47		MYH9_HUMAN (385-763): 9.36e-12: 71.6: 8.83