HitPredict

Interactor 1: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Interactor 2: PHC2 (Q8IXK0)
Polyhomeotic-like protein 2 (hPH2) (Early development regulatory protein 2)
Gene: PHC2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.481

Property	Details
Experiments	21988832
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 217 Hs			1 858
+	Hs
		557735 NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14		PHC2_HUMAN (1-858): 9.36e-98: 326: 100.00
+	Hs
		554292 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		MUC1_HUMAN (4-625): 1.16e-31: 135: 11.18
+	Hs
		924760 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		PRG4_HUMAN (14-621): 1.16e-13: 77.3: 8.72
+	Hs
		203218 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		SYNJ1_HUMAN (4-447): 1.1e-12: 74.2: 12.16
+	Hs
		411582 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		MUC1_HUMAN (4-625): 1.16e-31: 135: 11.18
+	Hs
		337335 ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46		MUC1_HUMAN (4-625): 1.16e-31: 135: 11.18
+	Hs
		203198 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		SYNJ1_HUMAN (4-447): 1.1e-12: 74.2: 12.16
+	Hs
		433560 LYN_HUMAN (129-215): 1.44e-11: 65: 22.47		MUC1_HUMAN (4-625): 1.16e-31: 135: 11.18
+	Hs
		522749 SRC_HUMAN (161-215): 3.76e-11: 63.8: 31.58		MUC1_HUMAN (4-625): 1.16e-31: 135: 11.18
+	Hs
		203208 NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14		SYNJ1_HUMAN (4-447): 1.1e-12: 74.2: 12.16
+	Hs
		433453 YES_HUMAN (59-215): 4.17e-13: 69.2: 14.91		SAM11_HUMAN (784-854): 9.87e-20: 96.3: 47.89
+	Hs
		297808 LYN_HUMAN (129-215): 1.44e-11: 65: 22.47		K0754_HUMAN (4-296): 3.92e-20: 98.9: 13.65
+	Hs
		433900 LYN_HUMAN (129-215): 1.44e-11: 65: 22.47		PHC3_HUMAN (12-763): 3.91e-14: 78.9: 23.81
+	Hs
		203228 ITSN1_HUMAN (137-216): 1.36e-12: 68.1: 25.00		SYNJ1_HUMAN (4-447): 1.1e-12: 74.2: 12.16