HitPredict

Interactor 1: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Interactor 2: MINK1 (Q8N4C8)
Misshapen-like kinase 1 (EC 2.7.11.1) (GCK family kinase MiNK) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (Mitogen-activated protein kinase kinase kinase kinase 6)
Gene: MINK1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	36736316
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005794 - Golgi apparatus GO:0005829 - cytosol GO:0030036 - actin cytoskeleton organization GO:0043408 - regulation of MAPK cascade and 1 others more... GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 217 Hs			1 1332
+	Hs
		411790 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		MINK1_HUMAN (1-1332): 0: 1277: 100.00
+	Hs
		557740 NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14		MINK1_HUMAN (1-1332): 0: 1277: 100.00
+	Hs
		324782 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		M4K4_HUMAN (1-1332): 0: 1026: 57.14
+	Hs
		557820 NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14		TNIK_HUMAN (1-1332): 0: 1098: 60.83
+	Hs
		324717 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		M4K4_HUMAN (1-1332): 0: 1026: 57.14
+	Hs
		324734 NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14		M4K4_HUMAN (1-1332): 0: 1026: 57.14
+	Mm
		956970 NCK1_MOUSE (5-145): 8.99e-23: 96.3: 33.14		M4K4_MOUSE (1-1332): 0: 993: 56.32
+	Hs
		924733 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		MYO3B_HUMAN (13-329): 7.71e-114: 390: 47.71
+	Dm
		993188 GRAP_DROME (1-215): 5.1e-62: 194: 62.79		Q7KV89_DROME (3-759): 6.63e-122: 408: 42.76
+	Hs
		924683 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		M4K3_HUMAN (19-441): 4.42e-110: 370: 37.24
+	Hs
		411778 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		MARK2_HUMAN (8-747): 3.42e-132: 427: 14.86
+	Hs
		924984 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		M4K5_HUMAN (5-307): 6.97e-71: 257: 45.60
+	Hs
		337455 ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46		STK4_HUMAN (5-469): 5.1e-119: 381: 32.99
+	Hs
		789058 ABL2_HUMAN (4-139): 9.61e-22: 94.7: 34.04		M3K10_HUMAN (21-845): 1.48e-113: 381: 19.26
+	Hs
		557731 NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14		M4K3_HUMAN (19-441): 4.42e-110: 370: 37.24
+	Hs
		412163 FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58		STK4_HUMAN (5-469): 5.1e-119: 381: 32.99
+	Hs
		1217590 ITSN2_HUMAN (2-61): 5.91e-15: 75: 36.67		M4K3_HUMAN (19-441): 4.42e-110: 370: 37.24
+	Hs
		557840 NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14		M4K5_HUMAN (5-307): 6.97e-71: 257: 45.60
+	Hs
		412425 FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58		M4K5_HUMAN (5-307): 6.97e-71: 257: 45.60
+	Hs
		442897 HCK_HUMAN (120-215): 1.21e-12: 68.1: 19.39		M4K5_HUMAN (5-307): 6.97e-71: 257: 45.60