HitPredict

Interactor 1: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Interactor 2: RIN3 (Q8TB24)
Ras and Rab interactor 3 (Ras interaction/interference protein 3)
Gene: RIN3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	32552912, 17474147
Identification Methods	affinity chromatography technology, peptide array
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 217 Hs			1 985
+	Hs
		69536 B0LPF3_HUMAN (1-217): 6.71e-76: 229: 100.00		RIN3_HUMAN (1-985): 1.3e-180: 552: 100.00
+	Hs
		411796 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		RIN3_HUMAN (1-985): 1.3e-180: 552: 100.00
+	Hs
		66465 A8K3B6_HUMAN (2-139): 3.88e-24: 100: 36.24		RIN3_HUMAN (1-985): 1.3e-180: 552: 100.00
+	Hs
		782808 CSK_HUMAN (2-139): 3.92e-24: 100: 36.24		RIN3_HUMAN (1-985): 1.3e-180: 552: 100.00
+	Hs
		557745 NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14		RIN3_HUMAN (1-985): 1.3e-180: 552: 100.00
+	Hs
		70370 B2R6S4_HUMAN (5-145): 8.9e-23: 96.3: 33.14		RIN3_HUMAN (1-985): 1.3e-180: 552: 100.00
+	Hs
		337509 ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46		RIN3_HUMAN (1-985): 1.3e-180: 552: 100.00
+	Hs
		166042 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		SYNJ2_HUMAN (181-524): 2.35e-51: 199: 19.77
+	Hs
		411889 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		MACF1_HUMAN (588-905): 2.12e-44: 178: 15.92
+	Hs
		557717 NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14		Q6NSK7_HUMAN (1-497): 1.57e-56: 213: 65.19
+	Hs
		203218 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		SYNJ1_HUMAN (311-736): 7.31e-12: 71.8: 11.24
+	Hs
		554292 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		MUC1_HUMAN (250-732): 1.28e-10: 67.9: 10.43
+	Hs
		166030 NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14		SYNJ2_HUMAN (181-524): 2.35e-51: 199: 19.77
+	Hs
		166023 ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46		SYNJ2_HUMAN (181-524): 2.35e-51: 199: 19.77
+	Hs
		203198 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		SYNJ1_HUMAN (311-736): 7.31e-12: 71.8: 11.24
+	Hs
		411582 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		MUC1_HUMAN (250-732): 1.28e-10: 67.9: 10.43
+	Mm
		337636 ABL1_MOUSE (4-139): 4.07e-22: 95.9: 35.46		RIN1_MOUSE (19-305): 1.31e-21: 102: 25.50
+	Hs
		337469 ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46		RIN1_HUMAN (6-327): 3.07e-21: 101: 26.32
+	Hs
		203208 NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14		SYNJ1_HUMAN (311-736): 7.31e-12: 71.8: 11.24
+	Hs
		337335 ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46		MUC1_HUMAN (250-732): 1.28e-10: 67.9: 10.43