HitPredict

Interactor 1: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Interactor 2: UBS3B (Q8TF42)
Ubiquitin-associated and SH3 domain-containing protein B (EC 3.1.3.48) (Cbl-interacting protein p70) (Suppressor of T-cell receptor signaling 1) (STS-1) (T-cell ubiquitin ligand 2) (TULA-2) (Tyrosine-protein phosphatase STS1/TULA2)
Gene: UBASH3B

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.70	0.60	0.650

Property	Details
Experiments	24189400, 22267732, 19380743
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 217 Hs			1 649
+	Hs
		782811 CSK_HUMAN (2-139): 3.92e-24: 100: 36.24		UBS3B_HUMAN (1-649): 0: 1066: 100.00
+	Hs
		557747 NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14		UBS3B_HUMAN (1-649): 0: 1066: 100.00
+	Hs
		337511 ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46		UBS3B_HUMAN (1-649): 0: 1066: 100.00
+	Hs
		782762 CSK_HUMAN (2-139): 3.92e-24: 100: 36.24		UBS3A_HUMAN (12-643): 0: 947: 43.37
+	Hs
		924447 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		GRB2_HUMAN (156-319): 1.37e-45: 163: 21.56
+	Hs
		924773 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		SH3K1_HUMAN (221-375): 5.02e-29: 124: 25.00
+	Mm
		1141153 GRB2_MOUSE (1-217): 2.48e-76: 230: 99.54		SH3K1_MOUSE (222-335): 2.37e-20: 97.6: 27.83
+	Hs
		924938 VAV3_HUMAN (1-212): 1.16e-43: 157: 22.00		GRB2_HUMAN (156-319): 1.37e-45: 163: 21.56
+	Hs
		782767 CSK_HUMAN (2-139): 3.92e-24: 100: 36.24		GRB2_HUMAN (156-319): 1.37e-45: 163: 21.56
+	Hs
		411817 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		SH3K1_HUMAN (221-375): 5.02e-29: 124: 25.00
+	Hs
		557655 NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14		GRB2_HUMAN (156-319): 1.37e-45: 163: 21.56
+	Hs
		337418 ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46		GRB2_HUMAN (156-319): 1.37e-45: 163: 21.56
+	Hs
		337526 ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46		SH3K1_HUMAN (221-375): 5.02e-29: 124: 25.00
+	Hs
		298944 ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46		SRBS2_HUMAN (230-317): 1.4e-22: 105: 27.84
+	Hs
		235470 NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14		VINEX_HUMAN (229-317): 1e-22: 104: 26.97
+	Hs
		298959 ABL2_HUMAN (4-139): 9.61e-22: 94.7: 34.04		SRBS2_HUMAN (230-317): 1.4e-22: 105: 27.84
+	Hs
		235462 ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46		VINEX_HUMAN (229-317): 1e-22: 104: 26.97
+	Hs
		337466 ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46		GRAP_HUMAN (156-317): 1.29e-24: 104: 19.16
+	Hs
		235483 ABL2_HUMAN (4-139): 9.61e-22: 94.7: 34.04		VINEX_HUMAN (229-317): 1e-22: 104: 26.97
+	Hs
		337548 ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46		SRBS1_HUMAN (258-317): 1.89e-18: 92.2: 40.00