HitPredict

Interactor 1: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Interactor 2: WIPF2 (Q8TF74)
WAS/WASL-interacting protein family member 2 (WASP-interacting protein-related protein) (WIP- and CR16-homologous protein) (WIP-related protein)
Gene: WIPF2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.93	0.60	0.748

Property	Details
Experiments	28514442, 31980649, 33961781, 20936779, 21706016, 21988832, unassigned2173
Identification Methods	affinity chromatography technology, two hybrid, anti tag coimmunoprecipitation, two hybrid pooling approach
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 217 Hs			1 440
+	Hs
		166042 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		SYNJ2_HUMAN (6-410): 2.46e-30: 126: 12.59
+	Hs
		924703 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		MINK1_HUMAN (78-414): 1.1e-28: 121: 16.76
+	Hs
		62643 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		WIPF3_HUMAN (24-435): 4.61e-21: 97.2: 29.33
+	Hs
		203218 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		SYNJ1_HUMAN (103-438): 2.34e-18: 90.3: 17.19
+	Hs
		554292 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		MUC1_HUMAN (142-437): 6.35e-11: 66.8: 11.15
+	Hs
		924760 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		PRG4_HUMAN (4-436): 1.76e-09: 62.2: 13.14
+	Hs
		411790 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		MINK1_HUMAN (78-414): 1.1e-28: 121: 16.76
+	Hs
		203198 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		SYNJ1_HUMAN (103-438): 2.34e-18: 90.3: 17.19
+	Hs
		557748 NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14		WIPF2_HUMAN (1-440): 4.28e-32: 128: 100.00
+	Hs
		166030 NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14		SYNJ2_HUMAN (6-410): 2.46e-30: 126: 12.59
+	Hs
		166023 ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46		SYNJ2_HUMAN (6-410): 2.46e-30: 126: 12.59
+	Hs
		557740 NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14		MINK1_HUMAN (78-414): 1.1e-28: 121: 16.76
+	Hs
		411582 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		MUC1_HUMAN (142-437): 6.35e-11: 66.8: 11.15
+	Hs
		1257321 ITSN2_HUMAN (2-61): 5.91e-15: 75: 36.67		WIPF2_HUMAN (1-440): 4.28e-32: 128: 100.00
+	Hs
		166056 ITSN2_HUMAN (2-61): 5.91e-15: 75: 36.67		SYNJ2_HUMAN (6-410): 2.46e-30: 126: 12.59
+	Hs
		166024 FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58		SYNJ2_HUMAN (6-410): 2.46e-30: 126: 12.59
+	Hs
		62640 NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14		WIPF3_HUMAN (24-435): 4.61e-21: 97.2: 29.33
+	Hs
		203208 NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14		SYNJ1_HUMAN (103-438): 2.34e-18: 90.3: 17.19
+	Hs
		62648 ITSN2_HUMAN (2-61): 5.91e-15: 75: 36.67		WIPF3_HUMAN (24-435): 4.61e-21: 97.2: 29.33
+	Hs
		337335 ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46		MUC1_HUMAN (142-437): 6.35e-11: 66.8: 11.15