HitPredict

Interactor 1: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Interactor 2: PDC6I (Q8WUM4)
Programmed cell death 6-interacting protein (PDCD6-interacting protein) (ALG-2-interacting protein 1) (ALG-2-interacting protein X) (Hp95)
Gene: PDCD6IP

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.613

Property	Details
Experiments	20936779, 21988832
Identification Methods	two hybrid, two hybrid pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005768 - endosome GO:0005829 - cytosol GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 217 Hs			1 868
+	Mm
		1141174 GRB2_MOUSE (1-217): 2.48e-76: 230: 99.54		PDC6I_MOUSE (1-868): 0: 638: 94.25
+	Hs
		1260413 ITSN2_HUMAN (2-61): 5.91e-15: 75: 36.67		PDC6I_HUMAN (1-868): 0: 677: 100.00
+	Hs
		412278 FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58		PDC6I_HUMAN (1-868): 0: 677: 100.00
+	Hs
		433429 YES_HUMAN (59-215): 4.17e-13: 69.2: 14.91		PDC6I_HUMAN (1-868): 0: 677: 100.00
+	Hs
		1078881 ITSN1_HUMAN (137-216): 1.36e-12: 68.1: 25.00		PDC6I_HUMAN (1-868): 0: 677: 100.00
+	Hs
		442861 HCK_HUMAN (120-215): 1.21e-12: 68.1: 19.39		PDC6I_HUMAN (1-868): 0: 677: 100.00
+	Hs
		924858 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		PTN23_HUMAN (3-868): 1.49e-131: 432: 23.93
+	Ce
		666203 SEM5_CAEEL (3-69): 6.24e-14: 70: 28.36		ALXA_CAEEL (4-831): 3.18e-164: 502: 37.92
+	Dm
		993211 GRAP_DROME (1-215): 5.1e-62: 194: 62.79		Q9VUH6_DROME (4-865): 5.54e-107: 365: 21.32
+	Hs
		1078907 ITSN1_HUMAN (137-216): 1.36e-12: 68.1: 25.00		PTN23_HUMAN (3-868): 1.49e-131: 432: 23.93
+	Hs
		724756 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		MYH9_HUMAN (163-716): 5.84e-59: 221: 15.01
+	Hs
		728465 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		MYH11_HUMAN (195-713): 8.34e-48: 187: 13.76
+	Hs
		725134 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		MYH10_HUMAN (197-713): 1.83e-42: 170: 13.08
+	Hs
		924521 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		EP300_HUMAN (527-867): 6.39e-32: 136: 13.70
+	Hs
		60561 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		VP37C_HUMAN (540-856): 2.14e-25: 110: 18.81
+	Hs
		412058 FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58		MYH9_HUMAN (163-716): 5.84e-59: 221: 15.01
+	Hs
		111443 J3QRU1_HUMAN (52-215): 3.95e-13: 69.6: 14.29		MYH9_HUMAN (163-716): 5.84e-59: 221: 15.01
+	Hs
		433272 YES_HUMAN (59-215): 4.17e-13: 69.2: 14.91		MYH9_HUMAN (163-716): 5.84e-59: 221: 15.01
+	Hs
		411694 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		EP300_HUMAN (527-867): 6.39e-32: 136: 13.70
+	Hs
		297808 LYN_HUMAN (129-215): 1.44e-11: 65: 22.47		K0754_HUMAN (709-860): 1.45e-11: 70.7: 23.42