HitPredict

Interactor 1: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Interactor 2: GAB3 (Q8WWW8)
GRB2-associated-binding protein 3 (GRB2-associated binder 3) (Growth factor receptor bound protein 2-associated protein 3)
Gene: GAB3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	11739737
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PH~SH3_1
Common GO terms	GO:0005737 - cytoplasm GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 217 Hs			1 586
+	Hs
		924959 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		GAB2_HUMAN (2-585): 1.27e-75: 255: 31.29
+	Mm
		1141175 GRB2_MOUSE (1-217): 2.48e-76: 230: 99.54		GAB2_MOUSE (2-585): 2.96e-68: 235: 32.62
+	Mm
		1114082 GRB2_MOUSE (1-217): 2.48e-76: 230: 99.54		Q3ZB59_MOUSE (2-585): 2.2e-67: 233: 32.47
+	Hs
		1040322 GRAP_HUMAN (1-213): 2.32e-66: 205: 56.74		GAB2_HUMAN (2-585): 1.27e-75: 255: 31.29
+	Mm
		69824 B1AT92_MOUSE (1-217): 3.26e-69: 212: 93.09		GAB2_MOUSE (2-585): 2.96e-68: 235: 32.62
+	Mm
		1141170 GRB2_MOUSE (1-217): 2.48e-76: 230: 99.54		GAB1_MOUSE (1-585): 1.34e-51: 190: 27.44
+	Hs
		924547 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		GAB1_HUMAN (1-585): 3.28e-51: 189: 26.37
+	Hs
		924640 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		PKHA7_HUMAN (5-478): 7.4e-49: 185: 11.91
+	Hs
		166042 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		SYNJ2_HUMAN (138-572): 8.44e-34: 139: 9.11
+	Hs
		924627 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		PKHS1_HUMAN (5-281): 5.87e-31: 128: 15.28
+	Hs
		924876 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		PKHA2_HUMAN (2-216): 1.06e-30: 126: 15.35
+	Hs
		1035413 VAV3_HUMAN (1-212): 1.16e-43: 157: 22.00		GAB1_HUMAN (1-585): 3.28e-51: 189: 26.37
+	Dm
		993221 GRAP_DROME (1-215): 5.1e-62: 194: 62.79		DOS_DROME (8-522): 1.95e-37: 150: 15.59
+	Hs
		411709 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		GAB1_HUMAN (1-585): 3.28e-51: 189: 26.37
+	Hs
		554292 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		MUC1_HUMAN (128-574): 8.61e-16: 83.3: 10.53
+	Hs
		203218 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		SYNJ1_HUMAN (110-572): 1.24e-12: 73.3: 9.79
+	Hs
		924702 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		SESQ1_HUMAN (6-113): 6.83e-12: 67.8: 28.70
+	Hs
		924651 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		MPRIP_HUMAN (8-301): 3.32e-10: 65.2: 13.38
+	Hs
		411582 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		MUC1_HUMAN (128-574): 8.61e-16: 83.3: 10.53
+	Hs
		203198 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		SYNJ1_HUMAN (110-572): 1.24e-12: 73.3: 9.79