HitPredict

Interactor 1: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Interactor 2: KRT35 (Q92764)
Keratin, type I cuticular Ha5 (Hair keratin, type I Ha5) (Keratin-35) (K35)
Gene: KRT35

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	19380743
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 217 Hs			1 455
+	Hs
		280559 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		KRT34_HUMAN (48-429): 5.17e-160: 459: 71.32
+	Hs
		359329 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		K1C14_HUMAN (95-434): 1.06e-145: 425: 56.77
+	Hs
		444346 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		K1C19_HUMAN (89-405): 7.13e-143: 415: 58.04
+	Hs
		924493 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		K1C17_HUMAN (90-408): 1.75e-123: 367: 60.82
+	Hs
		580010 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		K1C15_HUMAN (96-408): 3.69e-116: 350: 57.96
+	Hs
		445027 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		K1C16_HUMAN (93-408): 1.68e-115: 348: 58.86
+	Hs
		924574 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		KT33B_HUMAN (56-450): 1.95e-115: 346: 69.67
+	Hs
		280492 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		KT33A_HUMAN (48-450): 2.73e-115: 345: 69.85
+	Hs
		531343 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		K1C10_HUMAN (92-402): 2.59e-101: 315: 55.84
+	Hs
		213936 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		KRT86_HUMAN (2-454): 4.19e-93: 291: 26.41
+	Hs
		924469 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		KRT83_HUMAN (8-453): 3.88e-92: 289: 25.93
+	Hs
		924576 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		KRT81_HUMAN (6-454): 3.76e-92: 289: 26.20
+	Hs
		924679 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		K2C73_HUMAN (2-411): 4.94e-90: 285: 25.30
+	Hs
		924470 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		KRT85_HUMAN (2-452): 5.79e-87: 276: 25.96
+	Hs
		280786 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		KRT36_HUMAN (1-446): 1.06e-84: 269: 68.39
+	Hs
		924575 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		K1H2_HUMAN (1-455): 4.17e-83: 264: 64.40
+	Hs
		924895 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		KRT82_HUMAN (2-453): 8.29e-81: 260: 24.58
+	Hs
		531551 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		K2C5_HUMAN (1-417): 3.22e-73: 243: 23.64
+	Hs
		359480 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		K2C6A_HUMAN (65-432): 2.9e-73: 242: 24.13
+	Hs
		337481 ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46		K1H1_HUMAN (49-452): 5.82e-72: 234: 70.94