HitPredict

Interactor 1: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Interactor 2: SHIP1 (Q92835)
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 (EC 3.1.3.86) (Inositol polyphosphate-5-phosphatase D) (EC 3.1.3.56) (Inositol polyphosphate-5-phosphatase of 145 kDa) (SIP-145) (Phosphatidylinositol 4,5-bisphosphate 5-phosphatase) (EC 3.1.3.36) (SH2 domain-containing inositol 5'-phosphatase 1) (SH2 domain-containing inositol phosphatase 1) (SHIP-1) (p150Ship) (hp51CN)
Gene: INPP5D

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.82	1.00	0.909

Property	Details
Experiments	12149229, 11453982, 8723348, 8672490, 22267732
Identification Methods	affinity chromatography technology, unspecified method
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	SH2~SH2, SH2~SH3_1
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0007165 - signal transduction GO:0017124 - SH3 domain binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 217 Hs			1 1189
+	Mm
		1141165 GRB2_MOUSE (1-217): 2.48e-76: 230: 99.54		SHIP1_MOUSE (1-1189): 0: 858: 87.11
+	Hs
		557759 NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14		SHIP1_HUMAN (1-1189): 0: 883: 100.00
+	Mm
		337638 ABL1_MOUSE (4-139): 4.07e-22: 95.9: 35.46		SHIP1_MOUSE (1-1189): 0: 858: 87.11
+	Hs
		176424 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		SHIP2_HUMAN (3-1169): 0: 697: 39.77
+	Hs
		176332 ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46		SHIP2_HUMAN (3-1169): 0: 697: 39.77
+	Hs
		69199 A9UF07_HUMAN (4-139): 1.63e-21: 94: 35.46		SHIP2_HUMAN (3-1169): 0: 697: 39.77
+	Hs
		166042 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		SYNJ2_HUMAN (218-1188): 6.78e-172: 549: 18.76
+	Dm
		993185 GRAP_DROME (1-215): 5.1e-62: 194: 62.79		Q5U0V7_DROME (260-1001): 1.97e-163: 519: 18.89
+	Hs
		924485 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		OCRL_HUMAN (269-781): 8.78e-142: 453: 23.43
+	Hs
		166030 NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14		SYNJ2_HUMAN (218-1188): 6.78e-172: 549: 18.76
+	Hs
		166023 ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46		SYNJ2_HUMAN (218-1188): 6.78e-172: 549: 18.76
+	Hs
		166056 ITSN2_HUMAN (2-61): 5.91e-15: 75: 36.67		SYNJ2_HUMAN (218-1188): 6.78e-172: 549: 18.76
+	Hs
		166024 FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58		SYNJ2_HUMAN (218-1188): 6.78e-172: 549: 18.76
+	Hs
		411678 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		OCRL_HUMAN (269-781): 8.78e-142: 453: 23.43
+	Hs
		203218 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		SYNJ1_HUMAN (720-1118): 4.38e-12: 73.1: 10.05
+	Hs
		243120 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		SH21A_HUMAN (7-101): 2.92e-20: 89.7: 45.26
+	Hs
		203198 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		SYNJ1_HUMAN (720-1118): 4.38e-12: 73.1: 10.05
+	Hs
		243127 NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14		SH21A_HUMAN (7-101): 2.92e-20: 89.7: 45.26
+	Hs
		203208 NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14		SYNJ1_HUMAN (720-1118): 4.38e-12: 73.1: 10.05
+	Mm
		292397 FYN_MOUSE (161-215): 4.44e-14: 72.3: 31.58		SH21A_MOUSE (7-116): 3.21e-22: 95.1: 44.55