HitPredict

Interactor 1: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Interactor 2: RAD50 (Q92878)
DNA repair protein RAD50 (hRAD50) (EC 3.6.-.-)
Gene: RAD50

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	34348893
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 217 Hs			1 1312
+	Hs
		782815 CSK_HUMAN (2-139): 3.92e-24: 100: 36.24		RAD50_HUMAN (1-1312): 1.28e-115: 394: 100.00
+	Hs
		557761 NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14		RAD50_HUMAN (1-1312): 1.28e-115: 394: 100.00
+	Hs
		724756 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		MYH9_HUMAN (474-1226): 2.43e-26: 119: 10.19
+	Hs
		924736 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		MY18A_HUMAN (158-674): 1.53e-19: 97.7: 14.45
+	Hs
		725134 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		MYH10_HUMAN (44-596): 1.31e-16: 88.3: 13.20
+	Hs
		728465 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		MYH11_HUMAN (46-651): 5.68e-16: 86: 8.67
+	Hs
		411743 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		GRDN_HUMAN (530-1217): 5.01e-21: 102: 12.32
+	Hs
		411581 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		DESP_HUMAN (190-1069): 1.96e-10: 67.8: 18.71
+	Hs
		412058 FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58		MYH9_HUMAN (474-1226): 2.43e-26: 119: 10.19
+	Hs
		111443 J3QRU1_HUMAN (52-215): 3.95e-13: 69.6: 14.29		MYH9_HUMAN (474-1226): 2.43e-26: 119: 10.19
+	Hs
		433272 YES_HUMAN (59-215): 4.17e-13: 69.2: 14.91		MYH9_HUMAN (474-1226): 2.43e-26: 119: 10.19
+	Hs
		433620 LYN_HUMAN (129-215): 1.44e-11: 65: 22.47		MYH9_HUMAN (474-1226): 2.43e-26: 119: 10.19
+	Hs
		412287 FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58		MY18A_HUMAN (158-674): 1.53e-19: 97.7: 14.45
+	Hs
		1349277 ITSN2_HUMAN (2-61): 5.91e-15: 75: 36.67		DAPLE_HUMAN (420-1089): 3.01e-18: 93.5: 13.59
+	Hs
		433795 LYN_HUMAN (129-215): 1.44e-11: 65: 22.47		GRDN_HUMAN (530-1217): 5.01e-21: 102: 12.32
+	Hs
		551599 NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14		DESP_HUMAN (190-1069): 1.96e-10: 67.8: 18.71
+	Hs
		1057270 ITSN1_HUMAN (137-216): 1.36e-12: 68.1: 25.00		SMC1A_HUMAN (290-1274): 4.82e-19: 95.7: 11.17
+	Hs
		434048 LYN_HUMAN (129-215): 1.44e-11: 65: 22.47		DAPLE_HUMAN (420-1089): 3.01e-18: 93.5: 13.59
+	Hs
		411983 FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58		DESP_HUMAN (190-1069): 1.96e-10: 67.8: 18.71
+	Hs
		433558 LYN_HUMAN (129-215): 1.44e-11: 65: 22.47		DESP_HUMAN (190-1069): 1.96e-10: 67.8: 18.71