HitPredict

Interactor 1: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Interactor 2: PTPR2 (Q92932)
Receptor-type tyrosine-protein phosphatase N2 (R-PTP-N2) (EC 3.1.3.-) (EC 3.1.3.48) (Islet cell autoantigen-related protein) (IAR) (ICAAR) (Phogrin) [Cleaved into: IA-2beta60]
Gene: PTPRN2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	17474147
Identification Methods	peptide array
Interaction Type	physical association

Property	Details
Interacting Pfam domains	SH2~Y_phosphatase
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 217 Hs			1 1015
+	Hs
		411696 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		PTN13_HUMAN (90-1015): 2.13e-154: 508: 17.72
+	Hs
		411734 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		PTN14_HUMAN (94-1007): 4.8e-154: 489: 15.84
+	Hs
		411740 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		PTPRO_HUMAN (165-1011): 4.92e-151: 481: 16.15
+	Hs
		665853 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		PTN6_HUMAN (740-1014): 6.88e-118: 376: 37.98
+	Mm
		574006 GRB2_MOUSE (1-217): 2.48e-76: 230: 99.54		PTPRA_MOUSE (728-1006): 1.43e-108: 358: 36.07
+	Hs
		577009 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		PTPRA_HUMAN (728-1006): 2.2e-108: 357: 36.07
+	Hs
		617047 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		PTPRE_HUMAN (741-1006): 5.47e-99: 329: 36.16
+	Hs
		411612 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		PTN6_HUMAN (740-1014): 6.88e-118: 376: 37.98
+	Mm
		420374 GRB2_MOUSE (1-217): 2.48e-76: 230: 99.54		PTPRC_MOUSE (735-1013): 2.31e-66: 246: 28.34
+	Hs
		411565 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		PTPRF_HUMAN (75-1006): 2.95e-96: 337: 16.21
+	Hs
		146925 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		PTPRT_HUMAN (737-1008): 2.06e-62: 234: 32.14
+	Hs
		924529 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		PTPRJ_HUMAN (763-997): 1.07e-43: 175: 41.60
+	Mm
		411913 LCK_MOUSE (3-202): 2.89e-37: 137: 28.44		PTPRC_MOUSE (735-1013): 2.31e-66: 246: 28.34
+	Hs
		411597 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		PTPRG_HUMAN (123-1011): 2.65e-64: 239: 14.76
+	Hs
		411609 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		PTPRM_HUMAN (735-1009): 6.59e-62: 232: 31.10
+	Hs
		411728 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		PTPRK_HUMAN (734-1008): 1.02e-58: 222: 31.10
+	Hs
		411598 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		PTPRZ_HUMAN (708-1014): 1.11e-52: 204: 22.79
+	Hs
		617084 CSK_HUMAN (2-139): 3.92e-24: 100: 36.24		PTPRG_HUMAN (123-1011): 2.65e-64: 239: 14.76
+	Hs
		411695 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		PTPRJ_HUMAN (763-997): 1.07e-43: 175: 41.60
+	Hs
		617158 CSK_HUMAN (2-139): 3.92e-24: 100: 36.24		PTPRZ_HUMAN (708-1014): 1.11e-52: 204: 22.79