HitPredict

Interactor 1: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Interactor 2: RIT1 (Q92963)
GTP-binding protein Rit1 (EC 3.6.5.2) (Ras-like protein expressed in many tissues) (Ras-like without CAAX protein 1)
Gene: RIT1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	17474147
Identification Methods	peptide array
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0007165 - signal transduction GO:0007265 - Ras protein signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 217 Hs			1 219
+	Hs
		924814 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		RIT2_HUMAN (8-219): 6.77e-91: 267: 67.93
+	Hs
		924750 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		RAB8B_HUMAN (14-217): 1.47e-83: 248: 28.78
+	Hs
		924749 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		RAB1C_HUMAN (14-200): 4.2e-82: 244: 30.32
+	Hs
		924599 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		RB11B_HUMAN (11-210): 2.93e-81: 243: 27.59
+	Hs
		913994 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		RB11A_HUMAN (11-218): 1.48e-77: 233: 26.64
+	Hs
		348603 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		RASN_HUMAN (21-184): 3.19e-48: 158: 52.44
+	Hs
		349233 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		RASH_HUMAN (21-186): 2.02e-48: 158: 51.81
+	Hs
		488068 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		RRAS_HUMAN (19-188): 8.04e-48: 158: 51.77
+	Hs
		350048 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		RASK_HUMAN (21-195): 1.28e-47: 156: 50.29
+	Hs
		557649 NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14		RB11A_HUMAN (11-218): 1.48e-77: 233: 26.64
+	Hs
		506440 CSK_HUMAN (2-139): 3.92e-24: 100: 36.24		RALB_HUMAN (22-186): 1.38e-47: 157: 47.59
+	Hs
		488059 NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14		RRAS_HUMAN (19-188): 8.04e-48: 158: 51.77
+	Hs
		349172 ABL2_HUMAN (4-139): 9.61e-22: 94.7: 34.04		RASH_HUMAN (21-186): 2.02e-48: 158: 51.81
+	Hs
		349949 ABL2_HUMAN (4-139): 9.61e-22: 94.7: 34.04		RASK_HUMAN (21-195): 1.28e-47: 156: 50.29
+	Hs
		349105 VAV_HUMAN (2-60): 8.95e-15: 74.6: 42.37		RASH_HUMAN (21-186): 2.02e-48: 158: 51.81
+	Hs
		349066 FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58		RASH_HUMAN (21-186): 2.02e-48: 158: 51.81
+	Hs
		411957 FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58		RRAS_HUMAN (19-188): 8.04e-48: 158: 51.77
+	Hs
		348473 YES_HUMAN (59-215): 4.17e-13: 69.2: 14.91		RASN_HUMAN (21-184): 3.19e-48: 158: 52.44
+	Hs
		349069 YES_HUMAN (59-215): 4.17e-13: 69.2: 14.91		RASH_HUMAN (21-186): 2.02e-48: 158: 51.81
+	Hs
		349806 YES_HUMAN (59-215): 4.17e-13: 69.2: 14.91		RASK_HUMAN (21-195): 1.28e-47: 156: 50.29