HitPredict

Interactor 1: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Interactor 2: PEX13 (Q92968)
Peroxisomal membrane protein PEX13 (Peroxin-13)
Gene: PEX13

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	17474147
Identification Methods	peptide array
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 217 Hs			1 403
+	Hs
		557655 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		NCK1_HUMAN (254-399): 4.72e-34: 131: 19.86
+	Hs
		802558 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		CRK_HUMAN (248-395): 1.94e-33: 128: 21.80
+	Hs
		802818 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		CRKL_HUMAN (203-395): 1.89e-31: 123: 16.82
+	Hs
		924530 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		EPS8_HUMAN (200-362): 1.36e-23: 104: 13.50
+	Hs
		882224 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		BCAR1_HUMAN (274-400): 6.69e-23: 103: 22.05
+	Hs
		199510 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		EFS_HUMAN (271-373): 2.47e-22: 100: 28.04
+	Mm
		1141167 GRB2_MOUSE (1-217): 2.48e-76: 230: 99.54		CD2AP_MOUSE (165-377): 2.75e-14: 76.5: 14.09
+	Hs
		924801 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		SNX18_HUMAN (277-394): 1.49e-13: 74.2: 19.84
+	Hs
		924988 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		CD2AP_HUMAN (165-375): 2.28e-13: 73.8: 13.49
+	Hs
		411721 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		CASL_HUMAN (273-403): 1.29e-29: 123: 23.31
+	Hs
		411655 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		BCAR1_HUMAN (274-400): 6.69e-23: 103: 22.05
+	Mm
		337637 ABL1_MOUSE (4-139): 4.07e-22: 95.9: 35.46		NCK1_MOUSE (254-399): 2.2e-34: 133: 20.55
+	Hs
		557594 NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14		NCK1_HUMAN (254-399): 4.72e-34: 131: 19.86
+	Mm
		337631 ABL1_MOUSE (4-139): 4.07e-22: 95.9: 35.46		CRK_MOUSE (248-395): 1.14e-33: 129: 21.80
+	Hs
		208989 NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14		NCK2_HUMAN (257-399): 3.45e-32: 126: 20.98
+	Hs
		557691 NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14		CASL_HUMAN (273-403): 1.29e-29: 123: 23.31
+	Mm
		337621 ABL1_MOUSE (4-139): 4.07e-22: 95.9: 35.46		CRKL_MOUSE (203-395): 1.04e-30: 121: 17.35
+	Hs
		557645 NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14		BCAR1_HUMAN (274-400): 6.69e-23: 103: 22.05
+	Hs
		199501 NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14		EFS_HUMAN (271-373): 2.47e-22: 100: 28.04
+	Hs
		199495 ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46		EFS_HUMAN (271-373): 2.47e-22: 100: 28.04