HitPredict

Interactor 1: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Interactor 2: RADIL (Q96JH8)
Ras-associating and dilute domain-containing protein
Gene: RADIL

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	21706016
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0007165 - signal transduction
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 217 Hs			1 1075
+	Hs
		411905 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		MYO5A_HUMAN (392-807): 6.69e-83: 298: 17.82
+	Mm
		1141133 GRB2_MOUSE (1-217): 2.48e-76: 230: 99.54		DLG4_MOUSE (895-1066): 5.91e-26: 116: 18.61
+	Hs
		924466 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		DLG4_HUMAN (895-1066): 6.22e-26: 116: 18.61
+	Hs
		876349 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		AFAD_HUMAN (918-1075): 1.64e-20: 100: 21.88
+	Dm
		993190 GRAP_DROME (1-215): 5.1e-62: 194: 62.79		Q8IPP3_DROME (882-1075): 8.24e-26: 117: 20.40
+	Hs
		411698 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		DLG1_HUMAN (921-1066): 4.06e-20: 98.5: 19.73
+	Mm
		411930 LCK_MOUSE (3-202): 2.89e-37: 137: 28.44		DLG1_MOUSE (924-1066): 7.33e-20: 97.8: 20.14
+	Hs
		411696 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		PTN13_HUMAN (678-1075): 1.46e-16: 87.8: 15.16
+	Hs
		434073 LYN_HUMAN (129-215): 1.44e-11: 65: 22.47		NEB1_HUMAN (754-1069): 8.13e-38: 156: 15.79
+	Hs
		412128 FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58		DLG4_HUMAN (895-1066): 6.22e-26: 116: 18.61
+	Mm
		403445 SRC_MOUSE (161-215): 3.76e-11: 63.8: 31.58		DLG4_MOUSE (895-1066): 5.91e-26: 116: 18.61
+	Hs
		433300 YES_HUMAN (59-215): 4.17e-13: 69.2: 14.91		AFAD_HUMAN (918-1075): 1.64e-20: 100: 21.88
+	Hs
		433666 LYN_HUMAN (129-215): 1.44e-11: 65: 22.47		AFAD_HUMAN (918-1075): 1.64e-20: 100: 21.88
+	Hs
		522873 SRC_HUMAN (161-215): 3.76e-11: 63.8: 31.58		AFAD_HUMAN (918-1075): 1.64e-20: 100: 21.88
+	Hs
		433731 LYN_HUMAN (129-215): 1.44e-11: 65: 22.47		DLG1_HUMAN (921-1066): 4.06e-20: 98.5: 19.73
+	Hs
		433729 LYN_HUMAN (129-215): 1.44e-11: 65: 22.47		PTN13_HUMAN (678-1075): 1.46e-16: 87.8: 15.16