HitPredict

Interactor 1: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Interactor 2: EHMT2 (Q96KQ7)
Histone-lysine N-methyltransferase EHMT2 (EC 2.1.1.-) (EC 2.1.1.367) (Euchromatic histone-lysine N-methyltransferase 2) (HLA-B-associated transcript 8) (Histone H3-K9 methyltransferase 3) (H3-K9-HMTase 3) (Lysine N-methyltransferase 1C) (Protein G9a)
Gene: EHMT2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	17474147
Identification Methods	peptide array
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Ank_2~SH3_1
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 217 Hs			1 1210
+	Hs
		557772 NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14		EHMT2_HUMAN (21-1210): 0: 909: 100.00
+	Hs
		924484 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		ANK2_HUMAN (441-952): 4.59e-91: 326: 18.61
+	Hs
		924863 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		SUV92_HUMAN (928-1177): 2.53e-85: 285: 35.93
+	Hs
		557660 NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14		ANK2_HUMAN (441-952): 4.59e-91: 326: 18.61
+	Hs
		433701 LYN_HUMAN (129-215): 1.44e-11: 65: 22.47		ANK2_HUMAN (441-952): 4.59e-91: 326: 18.61
+	Hs
		411697 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		ANK3_HUMAN (624-1084): 7.02e-66: 248: 17.79
+	Hs
		557794 NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14		SUV92_HUMAN (928-1177): 2.53e-85: 285: 35.93
+	Hs
		337561 ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46		SUV92_HUMAN (928-1177): 2.53e-85: 285: 35.93
+	Hs
		412354 FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58		SUV92_HUMAN (928-1177): 2.53e-85: 285: 35.93
+	Hs
		434072 LYN_HUMAN (129-215): 1.44e-11: 65: 22.47		ANR50_HUMAN (542-1067): 5.3e-79: 287: 18.46
+	Hs
		203614 FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58		SUV91_HUMAN (861-1179): 1.67e-78: 266: 30.51
+	Hs
		433730 LYN_HUMAN (129-215): 1.44e-11: 65: 22.47		ANK3_HUMAN (624-1084): 7.02e-66: 248: 17.79
+	Hs
		337406 ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46		DAPK1_HUMAN (672-1049): 2.27e-52: 203: 17.06
+	Hs
		411885 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		KDIS_HUMAN (793-965): 2.43e-24: 113: 18.50
+	Hs
		411823 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		ASPP1_HUMAN (755-871): 8.39e-14: 78.5: 20.00
+	Hs
		257713 ITSN2_HUMAN (2-61): 5.91e-15: 75: 36.67		ANR17_HUMAN (51-672): 1.96e-25: 117: 7.86
+	Hs
		434071 LYN_HUMAN (129-215): 1.44e-11: 65: 22.47		KDIS_HUMAN (793-965): 2.43e-24: 113: 18.50
+	Hs
		433948 LYN_HUMAN (129-215): 1.44e-11: 65: 22.47		ASPP1_HUMAN (755-871): 8.39e-14: 78.5: 20.00