HitPredict

Interactor 1: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Interactor 2: ARAP1 (Q96P48)
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 (Centaurin-delta-2) (Cnt-d2)
Gene: ARAP1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.88	1.00	0.943

Property	Details
Experiments	28514442, 31980649, 33961781, 19380743, unassigned2173, 21706016
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	PH~SH3_1
Common GO terms	GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005794 - Golgi apparatus GO:0005829 - cytosol GO:0005886 - plasma membrane and 1 others more... GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 217 Hs			1 1450
+	Hs
		557775 NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14		ARAP1_HUMAN (1-1450): 0: 1074: 100.00
+	Hs
		411807 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		ARAP2_HUMAN (290-1448): 0: 782: 39.53
+	Hs
		412284 FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58		ARAP2_HUMAN (290-1448): 0: 782: 39.53
+	Hs
		64687 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		RHG32_HUMAN (647-1331): 2.29e-86: 314: 16.71
+	Hs
		195791 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		ASAP2_HUMAN (322-766): 7.55e-83: 296: 19.59
+	Hs
		924686 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		RHG12_HUMAN (595-1140): 4.27e-81: 288: 17.41
+	Dm
		993184 GRAP_DROME (1-215): 5.1e-62: 194: 62.79		Q0KHR5_DROME (624-1404): 8.84e-87: 314: 16.88
+	Hs
		924608 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		Q1RLN5_HUMAN (617-1140): 1.42e-77: 276: 17.04
+	Hs
		200212 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		SRGP3_HUMAN (623-1221): 8.56e-72: 264: 13.76
+	Hs
		64641 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		RHG32_HUMAN (647-1331): 2.29e-86: 314: 16.71
+	Hs
		64651 NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14		RHG32_HUMAN (647-1331): 2.29e-86: 314: 16.71
+	Hs
		195783 NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14		ASAP2_HUMAN (322-766): 7.55e-83: 296: 19.59
+	Hs
		64642 FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58		RHG32_HUMAN (647-1331): 2.29e-86: 314: 16.71
+	Mm
		70554 B2RQ57_MOUSE (4-139): 1.45e-20: 91.3: 33.33		AGAP2_MOUSE (277-760): 5.12e-81: 293: 17.25
+	Hs
		195776 FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58		ASAP2_HUMAN (322-766): 7.55e-83: 296: 19.59
+	Hs
		551038 NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14		CHIN_HUMAN (845-1139): 1.19e-70: 247: 22.37
+	Hs
		924893 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		RHG35_HUMAN (970-1118): 2.63e-20: 100: 36.91
+	Hs
		411755 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		RHG21_HUMAN (84-499): 2.61e-25: 116: 10.45
+	Hs
		557714 NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14		RHG21_HUMAN (84-499): 2.61e-25: 116: 10.45
+	Ce
		220207 SRC2_CAEEL (118-215): 1.65e-14: 73.4: 22.00		TG325_CAEEL (948-1116): 5.07e-18: 92.4: 37.06