HitPredict

Interactor 1: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Interactor 2: DOK1 (Q99704)
Docking protein 1 (Downstream of tyrosine kinase 1) (p62(dok)) (pp62)
Gene: DOK1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	15151996
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~SH3_1
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0007165 - signal transduction GO:0007265 - Ras protein signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 217 Hs			1 481
+	Mm
		956520 GRB2_MOUSE (1-217): 2.48e-76: 230: 99.54		DOK1_MOUSE (1-481): 0: 549: 83.23
+	Mm
		782845 CSK_MOUSE (2-139): 1.12e-23: 99.4: 35.57		DOK1_MOUSE (1-481): 0: 549: 83.23
+	Mm
		1141171 GRB2_MOUSE (1-217): 2.48e-76: 230: 99.54		DOK3_MOUSE (1-458): 4.81e-120: 360: 30.90
+	Hs
		924665 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		DOK3_HUMAN (1-458): 6.22e-116: 351: 31.21
+	Hs
		151763 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		IRS4_HUMAN (6-404): 5.55e-95: 314: 14.35
+	Rn
		724631 GRB2_RAT (1-217): 6.71e-76: 229: 100.00		IRS1_RAT (6-373): 3.69e-78: 267: 17.27
+	Mm
		724599 GRB2_MOUSE (1-217): 2.48e-76: 230: 99.54		IRS1_MOUSE (6-373): 1.1e-77: 265: 17.27
+	Hs
		724527 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		IRS1_HUMAN (6-373): 1.95e-76: 262: 16.33
+	Hs
		235035 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		DOK2_HUMAN (2-426): 3.33e-116: 349: 34.09
+	Mm
		946348 GRB2_MOUSE (1-217): 2.48e-76: 230: 99.54		IRS2_MOUSE (6-371): 1.55e-70: 245: 15.10
+	Rn
		94388 GRB2_RAT (1-217): 6.71e-76: 229: 100.00		F1MAL5_RAT (6-371): 8.44e-69: 240: 15.10
+	Hs
		924983 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		IRS2_HUMAN (6-384): 1.12e-67: 237: 14.05
+	Mm
		250951 CSK_MOUSE (2-139): 1.12e-23: 99.4: 35.57		DOK2_MOUSE (2-426): 3.12e-118: 354: 31.31
+	Hs
		151689 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		IRS4_HUMAN (6-404): 5.55e-95: 314: 14.35
+	Hs
		235051 CSK_HUMAN (2-139): 3.92e-24: 100: 36.24		DOK2_HUMAN (2-426): 3.33e-116: 349: 34.09
+	Dm
		993227 GRAP_DROME (1-215): 5.1e-62: 194: 62.79		IRS1_DROME (26-343): 3.54e-69: 239: 15.03
+	Rn
		88884 GRB2_RAT (1-217): 6.71e-76: 229: 100.00		D4A244_RAT (154-464): 1.16e-58: 203: 22.68
+	Mm
		1141149 GRB2_MOUSE (1-217): 2.48e-76: 230: 99.54		FRS2_MOUSE (154-464): 4.46e-56: 196: 21.73
+	Hs
		924725 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		FRS2_HUMAN (154-464): 2.53e-54: 191: 21.09
+	Hs
		411805 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		FRS2_HUMAN (154-464): 2.53e-54: 191: 21.09