HitPredict

Interactor 1: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Interactor 2: PTN18 (Q99952)
Tyrosine-protein phosphatase non-receptor type 18 (EC 3.1.3.48) (Brain-derived phosphatase)
Gene: PTPN18

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	21706016
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	SH2~Y_phosphatase
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 217 Hs			1 460
+	Hs
		924971 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		PTN22_HUMAN (6-389): 2.21e-146: 439: 38.70
+	Hs
		924500 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		PTN12_HUMAN (4-413): 2.43e-135: 409: 35.73
+	Hs
		665853 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		PTN6_HUMAN (5-325): 7.54e-131: 392: 32.95
+	Hs
		577009 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		PTPRA_HUMAN (4-307): 3.85e-109: 342: 32.79
+	Hs
		617047 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		PTPRE_HUMAN (5-307): 4.4e-101: 318: 30.77
+	Hs
		411596 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		PTPRB_HUMAN (5-315): 1.47e-127: 409: 31.66
+	Mm
		420374 GRB2_MOUSE (1-217): 2.48e-76: 230: 99.54		PTPRC_MOUSE (15-369): 6.92e-74: 254: 23.86
+	Hs
		411565 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		PTPRF_HUMAN (3-294): 1.09e-103: 341: 31.33
+	Hs
		146925 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		PTPRT_HUMAN (22-294): 8.09e-63: 222: 27.76
+	Hs
		411557 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		PTPRC_HUMAN (4-362): 2.82e-80: 272: 24.31
+	Hs
		663972 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		PTN4_HUMAN (54-292): 1.28e-48: 180: 39.59
+	Hs
		924529 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		PTPRJ_HUMAN (50-313): 1.3e-44: 169: 38.04
+	Mm
		719305 GRB2_MOUSE (1-217): 2.48e-76: 230: 99.54		PTN11_MOUSE (51-297): 6.26e-45: 167: 38.70
+	Hs
		924502 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		PTN11_HUMAN (51-297): 6.26e-45: 167: 38.70
+	Rn
		783504 GRB2_RAT (1-217): 6.71e-76: 229: 100.00		PTN11_RAT (51-297): 2.49e-44: 165: 38.31
+	Mm
		411913 LCK_MOUSE (3-202): 2.89e-37: 137: 28.44		PTPRC_MOUSE (15-369): 6.92e-74: 254: 23.86
+	Hs
		573654 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		PTN1_HUMAN (54-290): 2.48e-44: 162: 37.14
+	Mm
		574006 GRB2_MOUSE (1-217): 2.48e-76: 230: 99.54		PTPRA_MOUSE (13-292): 3.81e-32: 132: 26.56
+	Hs
		411597 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		PTPRG_HUMAN (4-316): 2.2e-57: 206: 24.77
+	Hs
		411598 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		PTPRZ_HUMAN (25-315): 2.81e-56: 203: 26.82