HitPredict

Interactor 1: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Interactor 2: PTN23 (Q9H3S7)
Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48) (His domain-containing protein tyrosine phosphatase) (HD-PTP) (Protein tyrosine phosphatase TD14) (PTP-TD14)
Gene: PTPN23

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.87	1.00	0.936

Property	Details
Experiments	28675297, 28514442, 33961781, 20936779, 21179510
Identification Methods	affinity chromatography technology, two hybrid, anti bait coimmunoprecipitation, far western blotting, anti tag coimmunoprecipitation, two hybrid pooling approach, pull down
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	SH2~Y_phosphatase
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005768 - endosome GO:0019901 - protein kinase binding and 1 others more... GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 217 Hs			1 1636
+	Hs
		924726 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		PDC6I_HUMAN (9-871): 7.58e-165: 523: 22.24
+	Mm
		1141174 GRB2_MOUSE (1-217): 2.48e-76: 230: 99.54		PDC6I_MOUSE (9-871): 1.47e-162: 517: 22.77
+	Hs
		573654 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		PTN1_HUMAN (1206-1566): 2.6e-121: 390: 26.39
+	Hs
		665853 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		PTN6_HUMAN (1159-1472): 7.88e-118: 386: 23.96
+	Hs
		924822 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		PTN18_HUMAN (1189-1596): 2.39e-115: 374: 25.64
+	Mm
		574006 GRB2_MOUSE (1-217): 2.48e-76: 230: 99.54		PTPRA_MOUSE (1205-1455): 8.37e-89: 311: 30.59
+	Hs
		577009 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		PTPRA_HUMAN (1205-1455): 7.92e-89: 310: 30.59
+	Hs
		411612 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		PTN6_HUMAN (1159-1472): 7.88e-118: 386: 23.96
+	Hs
		617047 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		PTPRE_HUMAN (1208-1453): 1.74e-80: 283: 32.55
+	Hs
		146925 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		PTPRT_HUMAN (1177-1455): 1.05e-54: 212: 22.73
+	Hs
		411565 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		PTPRF_HUMAN (1204-1453): 3.45e-77: 286: 29.92
+	Dm
		993211 GRAP_DROME (1-215): 5.1e-62: 194: 62.79		Q9VUH6_DROME (254-1486): 4.08e-59: 227: 13.48
+	Hs
		663972 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		PTN4_HUMAN (1220-1455): 2.79e-30: 132: 33.33
+	Mm
		719305 GRB2_MOUSE (1-217): 2.48e-76: 230: 99.54		PTN11_MOUSE (1195-1459): 4.76e-30: 129: 30.63
+	Rn
		783504 GRB2_RAT (1-217): 6.71e-76: 229: 100.00		PTN11_RAT (1195-1459): 6.28e-30: 129: 31.47
+	Hs
		924502 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		PTN11_HUMAN (1195-1459): 5.34e-30: 129: 30.63
+	Hs
		411609 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		PTPRM_HUMAN (1183-1455): 2.35e-53: 208: 21.86
+	Hs
		411728 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		PTPRK_HUMAN (1178-1455): 1.28e-50: 199: 22.54
+	Hs
		411597 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		PTPRG_HUMAN (1209-1470): 7.88e-39: 161: 26.18
+	Hs
		411596 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		PTPRB_HUMAN (1220-1451): 1.04e-29: 131: 33.75