HitPredict

Interactor 1: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Interactor 2: PKHA4 (Q9H4M7)
Pleckstrin homology domain-containing family A member 4 (PH domain-containing family A member 4) (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1)
Gene: PLEKHA4

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31091453
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~SH3_1
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 217 Hs			1 779
+	Hs
		411856 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00
+	Mm
		1141170 GRB2_MOUSE (1-217): 2.48e-76: 230: 99.54		GAB1_MOUSE (52-611): 1.35e-53: 199: 15.45
+	Hs
		924547 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		GAB1_HUMAN (52-611): 6.48e-53: 197: 13.92
+	Hs
		924640 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		PKHA7_HUMAN (2-440): 4.98e-50: 192: 28.02
+	Hs
		596390 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		RASA1_HUMAN (72-437): 2.74e-44: 174: 11.32
+	Hs
		924651 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		MPRIP_HUMAN (2-499): 4.76e-44: 173: 16.57
+	Hs
		924637 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		CYTSA_HUMAN (320-643): 3.92e-43: 171: 12.81
+	Hs
		924876 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		PKHA2_HUMAN (1-258): 2.68e-38: 149: 15.90
+	Hs
		924702 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		SESQ1_HUMAN (40-169): 5.2e-35: 135: 28.03
+	Dm
		993226 GRAP_DROME (1-215): 5.1e-62: 194: 62.79		Y34F_DROME (8-428): 5.48e-40: 161: 14.80
+	Hs
		1035413 VAV3_HUMAN (1-212): 1.16e-43: 157: 22.00		GAB1_HUMAN (52-611): 6.48e-53: 197: 13.92
+	Hs
		411709 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		GAB1_HUMAN (52-611): 6.48e-53: 197: 13.92
+	Hs
		411764 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		PKHA7_HUMAN (2-440): 4.98e-50: 192: 28.02
+	Hs
		411591 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		RASA1_HUMAN (72-437): 2.74e-44: 174: 11.32
+	Hs
		411772 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		MPRIP_HUMAN (2-499): 4.76e-44: 173: 16.57
+	Hs
		411755 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		RHG21_HUMAN (22-662): 1.96e-43: 172: 13.18
+	Hs
		411897 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		PKHA6_HUMAN (3-364): 2.39e-40: 162: 26.02
+	Hs
		411861 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		PKHA5_HUMAN (2-653): 1.62e-36: 150: 17.61
+	Hs
		596369 CSK_HUMAN (2-139): 3.92e-24: 100: 36.24		RASA1_HUMAN (72-437): 2.74e-44: 174: 11.32
+	Hs
		411904 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		FARP1_HUMAN (6-167): 1.07e-24: 112: 17.96