HitPredict

Interactor 1: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Interactor 2: PKHA2 (Q9HB19)
Pleckstrin homology domain-containing family A member 2 (PH domain-containing family A member 2) (Tandem PH domain-containing protein 2) (TAPP-2)
Gene: PLEKHA2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	19786618
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~SH3_1
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 217 Hs			1 425
+	Hs
		924640 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		PKHA7_HUMAN (118-420): 6.77e-39: 151: 16.81
+	Hs
		195791 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		ASAP2_HUMAN (54-361): 7.72e-35: 139: 15.24
+	Hs
		924651 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		MPRIP_HUMAN (110-388): 7.33e-34: 136: 15.09
+	Hs
		924812 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		CYH2_HUMAN (134-322): 3.98e-34: 133: 21.50
+	Hs
		411764 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		PKHA7_HUMAN (118-420): 6.77e-39: 151: 16.81
+	Dm
		993226 GRAP_DROME (1-215): 5.1e-62: 194: 62.79		Y34F_DROME (183-298): 1.17e-18: 90.7: 27.97
+	Hs
		411861 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		PKHA5_HUMAN (118-392): 3.97e-37: 146: 15.05
+	Hs
		411904 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		FARP1_HUMAN (27-311): 1.73e-35: 141: 15.46
+	Hs
		411897 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		PKHA6_HUMAN (140-410): 1.5e-34: 138: 19.36
+	Hs
		411772 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		MPRIP_HUMAN (110-388): 7.33e-34: 136: 15.09
+	Hs
		195783 NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14		ASAP2_HUMAN (54-361): 7.72e-35: 139: 15.24
+	Hs
		299235 VAV_HUMAN (2-60): 8.95e-15: 74.6: 42.37		FARP2_HUMAN (78-329): 6.57e-40: 154: 17.83
+	Hs
		299283 Q96D37_HUMAN (2-60): 8.82e-15: 74.6: 42.37		FARP2_HUMAN (78-329): 6.57e-40: 154: 17.83
+	Hs
		433388 YES_HUMAN (59-215): 4.17e-13: 69.2: 14.91		PKHA7_HUMAN (118-420): 6.77e-39: 151: 16.81
+	Hs
		195776 FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58		ASAP2_HUMAN (54-361): 7.72e-35: 139: 15.24
+	Hs
		195777 YES_HUMAN (59-215): 4.17e-13: 69.2: 14.91		ASAP2_HUMAN (54-361): 7.72e-35: 139: 15.24
+	Hs
		411807 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		ARAP2_HUMAN (185-326): 3.94e-12: 70.4: 18.18
+	Hs
		195795 ITSN1_HUMAN (137-216): 1.36e-12: 68.1: 25.00		ASAP2_HUMAN (54-361): 7.72e-35: 139: 15.24
+	Hs
		212314 ITSN1_HUMAN (137-216): 1.36e-12: 68.1: 25.00		CYH3_HUMAN (140-314): 6.06e-31: 124: 21.00
+	Hs
		412284 FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58		ARAP2_HUMAN (185-326): 3.94e-12: 70.4: 18.18