HitPredict

Interactor 1: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Interactor 2: MLXPL (Q9NP71)
Carbohydrate-responsive element-binding protein (ChREBP) (Class D basic helix-loop-helix protein 14) (bHLHd14) (MLX interactor) (MLX-interacting protein-like) (WS basic-helix-loop-helix leucine zipper protein) (WS-bHLH) (Williams-Beuren syndrome chromosomal region 14 protein)
Gene: MLXIPL

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.481

Property	Details
Experiments	21988832
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 217 Hs			1 852
+	Hs
		924858 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		PTN23_HUMAN (182-645): 2.47e-21: 102: 15.78
+	Hs
		554292 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		MUC1_HUMAN (345-830): 8.61e-13: 74.4: 11.09
+	Hs
		924760 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		PRG4_HUMAN (147-643): 7.93e-10: 65.2: 10.26
+	Hs
		203218 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		SYNJ1_HUMAN (137-482): 1.6e-09: 64: 9.38
+	Hs
		411582 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		MUC1_HUMAN (345-830): 8.61e-13: 74.4: 11.09
+	Hs
		203198 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		SYNJ1_HUMAN (137-482): 1.6e-09: 64: 9.38
+	Hs
		297808 LYN_HUMAN (129-215): 1.44e-11: 65: 22.47		K0754_HUMAN (293-844): 6.68e-29: 127: 12.66
+	Hs
		1078907 ITSN1_HUMAN (137-216): 1.36e-12: 68.1: 25.00		PTN23_HUMAN (182-645): 2.47e-21: 102: 15.78
+	Hs
		337335 ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46		MUC1_HUMAN (345-830): 8.61e-13: 74.4: 11.09
+	Hs
		523149 SRC_HUMAN (161-215): 3.76e-11: 63.8: 31.58		PTN23_HUMAN (182-645): 2.47e-21: 102: 15.78
+	Hs
		275227 GRAP2_HUMAN (3-55): 1.58e-10: 61.3: 39.62		PTN23_HUMAN (182-645): 2.47e-21: 102: 15.78
+	Hs
		203208 NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14		SYNJ1_HUMAN (137-482): 1.6e-09: 64: 9.38
+	Mm
		292687 GRAP2_MOUSE (3-55): 1.57e-10: 61.5: 37.74		PTN23_MOUSE (182-728): 4.2e-19: 95.1: 15.70
+	Hs
		412362 FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58		MAGE1_HUMAN (299-648): 1.41e-13: 76.9: 18.72
+	Hs
		433560 LYN_HUMAN (129-215): 1.44e-11: 65: 22.47		MUC1_HUMAN (345-830): 8.61e-13: 74.4: 11.09
+	Hs
		522749 SRC_HUMAN (161-215): 3.76e-11: 63.8: 31.58		MUC1_HUMAN (345-830): 8.61e-13: 74.4: 11.09
+	Hs
		257713 ITSN2_HUMAN (2-61): 5.91e-15: 75: 36.67		ANR17_HUMAN (243-688): 5.19e-09: 62.4: 12.15
+	Hs
		203228 ITSN1_HUMAN (137-216): 1.36e-12: 68.1: 25.00		SYNJ1_HUMAN (137-482): 1.6e-09: 64: 9.38
+	Hs
		855816 VAV2_HUMAN (3-56): 4.83e-11: 63.5: 38.18		TITIN_HUMAN (374-544): 3.34e-10: 66.5: 20.20
+	Hs
		433853 LYN_HUMAN (129-215): 1.44e-11: 65: 22.47		MICA3_HUMAN (136-728): 5.89e-09: 62.1: 10.28