HitPredict

Interactor 1: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Interactor 2: Q9NPR5 (Q9NPR5)
PTPRJ, protein tyrosine phosphatase receptor J, eta
Gene: Q9NPR5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.80	0.514

Property	Details
Experiments	21706016
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	SH2~fn3
Common GO terms	-
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 217 Hs			1 425
+	Hs
		924529 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		PTPRJ_HUMAN (42-401): 7.34e-29: 121: 18.69
+	Hs
		363045 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		FINC_HUMAN (183-425): 3.46e-23: 104: 13.54
+	Hs
		411565 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		PTPRF_HUMAN (6-367): 2.04e-39: 153: 13.71
+	Hs
		411695 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		PTPRJ_HUMAN (42-401): 7.34e-29: 121: 18.69
+	Hs
		411959 FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58		PTPRF_HUMAN (6-367): 2.04e-39: 153: 13.71
+	Hs
		412016 FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58		PTPRD_HUMAN (1-399): 3.44e-38: 149: 13.01
+	Hs
		782783 CSK_HUMAN (2-139): 3.92e-24: 100: 36.24		PTPRJ_HUMAN (42-401): 7.34e-29: 121: 18.69
+	Hs
		411596 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		PTPRB_HUMAN (47-347): 2.26e-09: 61.9: 13.58
+	Mm
		56907 FYN_MOUSE (161-215): 4.44e-14: 72.3: 31.58		PTPRF_MOUSE (5-300): 1.51e-30: 126: 12.39
+	Hs
		557632 NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14		DCC_HUMAN (23-425): 1.76e-16: 84: 10.66
+	Hs
		362685 FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58		FINC_HUMAN (183-425): 3.46e-23: 104: 13.54
+	Hs
		362705 YES_HUMAN (59-215): 4.17e-13: 69.2: 14.91		FINC_HUMAN (183-425): 3.46e-23: 104: 13.54
+	Dm
		337644 ABL_DROME (4-135): 1e-22: 97.4: 37.68		LAR_DROME (73-348): 6.12e-13: 73.2: 12.58
+	Hs
		616905 CSK_HUMAN (2-139): 3.92e-24: 100: 36.24		PTPRB_HUMAN (47-347): 2.26e-09: 61.9: 13.58
+	Hs
		855816 VAV2_HUMAN (3-56): 4.83e-11: 63.5: 38.18		TITIN_HUMAN (33-263): 2.99e-10: 64.9: 14.73
+	Hs
		433804 LYN_HUMAN (129-215): 1.44e-11: 65: 22.47		SDK2_HUMAN (45-424): 7.42e-09: 60.1: 8.72