HitPredict

Interactor 1: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Interactor 2: ABI3 (Q9P2A4)
ABI gene family member 3 (New molecule including SH3) (Nesh)
Gene: ABI3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.573

Property	Details
Experiments	25416956
Identification Methods	two hybrid, two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0017124 - SH3 domain binding GO:0030036 - actin cytoskeleton organization
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 217 Hs			1 366
+	Hs
		924570 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		SRC8_HUMAN (40-363): 2.07e-42: 157: 16.12
+	Hs
		536574 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		HCLS1_HUMAN (20-363): 7.34e-37: 140: 13.98
+	Hs
		924943 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		ASAP1_HUMAN (223-362): 2.82e-24: 106: 23.03
+	Hs
		924696 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		ABI1_HUMAN (124-363): 7.31e-21: 95.5: 24.49
+	Dm
		993202 GRAP_DROME (1-215): 5.1e-62: 194: 62.79		Q9VDF4_DROME (89-363): 8.81e-31: 124: 16.33
+	Hs
		924447 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		GRB2_HUMAN (312-363): 4.03e-14: 72.7: 28.30
+	Rn
		71363 B2RZ33_RAT (5-145): 8.99e-23: 96.3: 33.14		SRC8_RAT (40-363): 3.67e-43: 158: 13.89
+	Mm
		411921 LCK_MOUSE (3-202): 2.89e-37: 137: 28.44		HCLS1_MOUSE (86-363): 1.57e-28: 117: 13.67
+	Hs
		337550 ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46		PACN1_HUMAN (11-363): 5.47e-37: 140: 12.67
+	Hs
		411788 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		ABI1_HUMAN (124-363): 7.31e-21: 95.5: 24.49
+	Hs
		924938 VAV3_HUMAN (1-212): 1.16e-43: 157: 22.00		GRB2_HUMAN (312-363): 4.03e-14: 72.7: 28.30
+	Hs
		557806 NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14		ABI2_HUMAN (109-363): 4.36e-25: 108: 23.18
+	Hs
		557823 NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14		ASAP1_HUMAN (223-362): 2.82e-24: 106: 23.03
+	Mm
		337634 ABL1_MOUSE (4-139): 4.07e-22: 95.9: 35.46		ABI1_MOUSE (272-363): 1.7e-21: 97.4: 44.57
+	Dm
		337662 ABL_DROME (4-135): 1e-22: 97.4: 37.68		Q9Y0S9_DROME (260-364): 1.16e-20: 94.7: 38.32
+	Hs
		557737 NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14		ABI1_HUMAN (124-363): 7.31e-21: 95.5: 24.49
+	Hs
		337502 ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46		ABI1_HUMAN (124-363): 7.31e-21: 95.5: 24.49
+	Hs
		782767 CSK_HUMAN (2-139): 3.92e-24: 100: 36.24		GRB2_HUMAN (312-363): 4.03e-14: 72.7: 28.30
+	Hs
		557655 NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14		GRB2_HUMAN (312-363): 4.03e-14: 72.7: 28.30
+	Hs
		337418 ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46		GRB2_HUMAN (312-363): 4.03e-14: 72.7: 28.30