HitPredict

Interactor 1: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Interactor 2: RHG20 (Q9P2F6)
Rho GTPase-activating protein 20 (Rho-type GTPase-activating protein 20)
Gene: ARHGAP20

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	21706016
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 217 Hs			1 1191
+	Hs
		64687 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		RHG32_HUMAN (318-1066): 3e-105: 368: 16.23
+	Hs
		924636 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		RHG17_HUMAN (180-1003): 2.72e-104: 352: 14.54
+	Hs
		200212 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		SRGP3_HUMAN (185-839): 5.07e-79: 284: 13.45
+	Hs
		64641 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		RHG32_HUMAN (318-1066): 3e-105: 368: 16.23
+	Hs
		924893 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		RHG35_HUMAN (219-568): 7.74e-72: 265: 16.44
+	Hs
		411755 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		RHG21_HUMAN (173-974): 1.04e-100: 354: 12.55
+	Hs
		411763 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		RHG17_HUMAN (180-1003): 2.72e-104: 352: 14.54
+	Hs
		924852 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		RGAP1_HUMAN (270-619): 4.65e-66: 237: 19.78
+	Hs
		64651 NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14		RHG32_HUMAN (318-1066): 3e-105: 368: 16.23
+	Hs
		557714 NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14		RHG21_HUMAN (173-974): 1.04e-100: 354: 12.55
+	Hs
		924608 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		Q1RLN5_HUMAN (358-553): 8.17e-59: 219: 24.88
+	Hs
		924686 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		RHG12_HUMAN (358-553): 2.66e-58: 219: 24.88
+	Hs
		337492 ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46		RHG17_HUMAN (180-1003): 2.72e-104: 352: 14.54
+	Hs
		69699 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		B1AHC3_HUMAN (361-554): 6.39e-58: 212: 28.79
+	Hs
		81928 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		B7ZMA4_HUMAN (361-554): 3.7e-57: 208: 26.64
+	Hs
		253421 ITSN2_HUMAN (2-61): 5.91e-15: 75: 36.67		SRGP2_HUMAN (185-956): 7.24e-83: 295: 13.90
+	Mm
		337622 ABL1_MOUSE (4-139): 4.07e-22: 95.9: 35.46		3BP1_MOUSE (340-573): 8.75e-67: 241: 23.24
+	Hs
		337603 ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46		3BP1_HUMAN (340-574): 3.74e-66: 239: 23.14
+	Hs
		551038 NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14		CHIN_HUMAN (340-551): 3.65e-67: 235: 20.18
+	Hs
		557642 NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14		CHIO_HUMAN (340-551): 8.39e-67: 235: 22.48