HitPredict

Interactor 1: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Interactor 2: EP15R (Q9UBC2)
Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R)
Gene: EPS15L1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	21706016
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 217 Hs			1 864
+	Hs
		787889 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		EPS15_HUMAN (1-862): 3.59e-115: 374: 42.20
+	Hs
		337577 ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46		EP15R_HUMAN (1-864): 1.18e-150: 466: 100.00
+	Hs
		1349279 ITSN2_HUMAN (2-61): 5.91e-15: 75: 36.67		EP15R_HUMAN (1-864): 1.18e-150: 466: 100.00
+	Hs
		61738 A6H8W8_HUMAN (2-61): 6.74e-15: 75: 36.67		EP15R_HUMAN (1-864): 1.18e-150: 466: 100.00
+	Hs
		1078923 ITSN1_HUMAN (137-216): 1.36e-12: 68.1: 25.00		EP15R_HUMAN (1-864): 1.18e-150: 466: 100.00
+	Hs
		557629 NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14		EPS15_HUMAN (1-862): 3.59e-115: 374: 42.20
+	Hs
		337383 ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46		EPS15_HUMAN (1-862): 3.59e-115: 374: 42.20
+	Hs
		69204 A9UF07_HUMAN (4-139): 1.63e-21: 94: 35.46		EPS15_HUMAN (1-862): 3.59e-115: 374: 42.20
+	Hs
		61732 A6H8W8_HUMAN (2-61): 6.74e-15: 75: 36.67		EPS15_HUMAN (1-862): 3.59e-115: 374: 42.20
+	Hs
		787985 ITSN2_HUMAN (2-61): 5.91e-15: 75: 36.67		EPS15_HUMAN (1-862): 3.59e-115: 374: 42.20
+	Hs
		412069 FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58		EPS15_HUMAN (1-862): 3.59e-115: 374: 42.20
+	Hs
		787920 ITSN1_HUMAN (137-216): 1.36e-12: 68.1: 25.00		EPS15_HUMAN (1-862): 3.59e-115: 374: 42.20
+	Mm
		788010 ITSN1_MOUSE (137-216): 1.77e-12: 67.7: 25.00		EPS15_MOUSE (1-862): 8.21e-97: 325: 41.30
+	Hs
		924713 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		REPS2_HUMAN (14-99): 3.33e-12: 72.3: 24.42
+	Hs
		411758 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		MRCKA_HUMAN (415-784): 2.54e-20: 99.4: 7.87
+	Hs
		1078919 ITSN2_HUMAN (2-61): 5.91e-15: 75: 36.67		ITSN1_HUMAN (1-522): 2.39e-32: 138: 13.31
+	Hs
		1078828 ITSN1_HUMAN (137-216): 1.36e-12: 68.1: 25.00		ITSN1_HUMAN (1-522): 2.39e-32: 138: 13.31
+	Hs
		1349275 ITSN2_HUMAN (2-61): 5.91e-15: 75: 36.67		ITSN2_HUMAN (2-531): 1.52e-24: 112: 11.86
+	Hs
		1078872 ITSN1_HUMAN (137-216): 1.36e-12: 68.1: 25.00		REPS2_HUMAN (14-99): 3.33e-12: 72.3: 24.42