HitPredict

Interactor 1: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Interactor 2: MYO1A (Q9UBC5)
Unconventional myosin-Ia (Brush border myosin I) (BBM-I) (BBMI) (Myosin I heavy chain) (MIHC)
Gene: MYO1A

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	12577067
Identification Methods	pull down
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 217 Hs			1 1043
+	Hs
		214548 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		MYO1B_HUMAN (3-1042): 0: 1079: 50.04
+	Hs
		117655 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		MYO1C_HUMAN (5-1043): 0: 1016: 41.58
+	Hs
		214469 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		MYO1B_HUMAN (3-1042): 0: 1079: 50.04
+	Hs
		117557 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		MYO1C_HUMAN (5-1043): 0: 1016: 41.58
+	Hs
		214472 LYN_HUMAN (129-215): 1.44e-11: 65: 22.47		MYO1B_HUMAN (3-1042): 0: 1079: 50.04
+	Hs
		297270 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		MYO1D_HUMAN (7-1040): 0: 990: 38.67
+	Hs
		297273 LYN_HUMAN (129-215): 1.44e-11: 65: 22.47		MYO1D_HUMAN (7-1040): 0: 990: 38.67
+	Hs
		433732 LYN_HUMAN (129-215): 1.44e-11: 65: 22.47		MYO1E_HUMAN (9-722): 0: 587: 44.34
+	Hs
		728465 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		MYH11_HUMAN (745-1031): 1.13e-09: 65: 8.74
+	Hs
		724756 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		MYH9_HUMAN (648-1043): 2.39e-09: 63.8: 9.29
+	Hs
		725134 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		MYH10_HUMAN (685-1018): 2.62e-09: 63.8: 11.68
+	Hs
		411905 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		MYO5A_HUMAN (593-1027): 9.79e-14: 78.1: 10.89
+	Hs
		412058 FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58		MYH9_HUMAN (648-1043): 2.39e-09: 63.8: 9.29
+	Hs
		111443 J3QRU1_HUMAN (52-215): 3.95e-13: 69.6: 14.29		MYH9_HUMAN (648-1043): 2.39e-09: 63.8: 9.29
+	Hs
		433272 YES_HUMAN (59-215): 4.17e-13: 69.2: 14.91		MYH9_HUMAN (648-1043): 2.39e-09: 63.8: 9.29
+	Hs
		433620 LYN_HUMAN (129-215): 1.44e-11: 65: 22.47		MYH9_HUMAN (648-1043): 2.39e-09: 63.8: 9.29