HitPredict

Interactor 1: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Interactor 2: ALK (Q9UM73)
ALK tyrosine kinase receptor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD antigen CD246)
Gene: ALK

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.79	1.00	0.890

Property	Details
Experiments	16105984, 14968112, 35384245, 9819383
Identification Methods	affinity chromatography technology, proximity labelling technology, pull down
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~SH3_1
Common GO terms	GO:0005886 - plasma membrane GO:0007165 - signal transduction GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 217 Hs			1 1620
+	Hs
		666572 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		LTK_HUMAN (606-1458): 6.35e-175: 550: 53.24
+	Hs
		434170 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		RET_HUMAN (842-1477): 4.8e-137: 455: 23.56
+	Hs
		872610 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		EPHB1_HUMAN (938-1436): 5.66e-129: 429: 25.25
+	Hs
		924589 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		ERBB4_HUMAN (882-1547): 2.9e-122: 418: 22.24
+	Mm
		872621 GRB2_MOUSE (1-217): 2.48e-76: 230: 99.54		EPHB2_MOUSE (938-1436): 2.64e-124: 416: 23.46
+	Hs
		665574 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		EPHB2_HUMAN (938-1436): 2.19e-123: 416: 23.26
+	Hs
		601492 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		FGFR2_HUMAN (952-1433): 9.52e-123: 407: 25.24
+	Hs
		789054 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		ABL2_HUMAN (1103-1526): 1.55e-118: 405: 32.47
+	Hs
		665389 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		EPHA3_HUMAN (943-1427): 7.27e-120: 404: 25.87
+	Hs
		609244 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		FGFR3_HUMAN (952-1449): 6.42e-121: 401: 26.31
+	Hs
		507939 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		FGFR1_HUMAN (952-1454): 2.04e-118: 395: 26.06
+	Mm
		972995 GRB2_MOUSE (1-217): 2.48e-76: 230: 99.54		TIE2_MOUSE (954-1389): 3.85e-115: 394: 28.79
+	Hs
		411352 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		INSR_HUMAN (973-1436): 1.01e-112: 392: 34.25
+	Hs
		435602 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		IGF1R_HUMAN (1037-1385): 8.86e-111: 386: 39.77
+	Hs
		924571 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		FAK2_HUMAN (1054-1518): 4.66e-109: 374: 27.45
+	Hs
		537729 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		INSRR_HUMAN (1082-1384): 2.38e-70: 262: 43.46
+	Rn
		728442 GRB2_RAT (1-217): 6.71e-76: 229: 100.00		NTRK1_RAT (1111-1390): 1.4e-63: 235: 42.71
+	Hs
		384619 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		NTRK1_HUMAN (1111-1392): 5.05e-62: 230: 42.07
+	Hs
		924601 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		NTRK3_HUMAN (1093-1375): 2.69e-59: 223: 39.03
+	Mm
		963044 GRB2_MOUSE (1-217): 2.48e-76: 230: 99.54		UFO_MOUSE (1039-1393): 3.29e-55: 211: 35.60