HitPredict

Interactor 1: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Interactor 2: DYN3 (Q9UQ16)
Dynamin-3 (EC 3.6.5.5) (Dynamin, testicular) (T-dynamin)
Gene: DNM3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.90	1.00	0.949

Property	Details
Experiments	28514442, 31980649, 33961781, 19380743, 21706016, unassigned2173
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	PH~SH3_1
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0031623 - receptor internalization GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 217 Hs			1 869
+	Mm
		1141147 GRB2_MOUSE (1-217): 2.48e-76: 230: 99.54		DYN3_MOUSE (1-869): 0: 1071: 95.99
+	Hs
		840663 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		DYN2_HUMAN (1-869): 0: 1041: 79.21
+	Mm
		760474 GRB2_MOUSE (1-217): 2.48e-76: 230: 99.54		DYN2_MOUSE (1-869): 0: 1038: 79.21
+	Mm
		760450 GRB2_MOUSE (1-217): 2.48e-76: 230: 99.54		DYN1_MOUSE (1-847): 0: 1035: 78.90
+	Hs
		924499 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		DYN1_HUMAN (1-852): 0: 1035: 78.56
+	Rn
		599402 GRB2_RAT (1-217): 6.71e-76: 229: 100.00		DYN1_RAT (1-852): 0: 1028: 78.22
+	Hs
		840686 GRAP_HUMAN (1-213): 2.32e-66: 205: 56.74		DYN2_HUMAN (1-869): 0: 1041: 79.21
+	Hs
		411645 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		DYN2_HUMAN (1-869): 0: 1041: 79.21
+	Hs
		337597 ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46		DYN3_HUMAN (1-869): 0: 1080: 100.00
+	Dm
		649302 GRAP_DROME (1-215): 5.1e-62: 194: 62.79		DYN_DROME (6-861): 0: 974: 64.46
+	Hs
		412411 FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58		DYN3_HUMAN (1-869): 0: 1080: 100.00
+	Hs
		337399 ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46		DYN2_HUMAN (1-869): 0: 1041: 79.21
+	Hs
		557664 NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14		DYN1_HUMAN (1-852): 0: 1035: 78.56
+	Hs
		337437 ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46		DYN1_HUMAN (1-852): 0: 1035: 78.56
+	Hs
		840840 ITSN2_HUMAN (2-61): 5.91e-15: 75: 36.67		DYN2_HUMAN (1-869): 0: 1041: 79.21
+	Hs
		412090 FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58		DYN2_HUMAN (1-869): 0: 1041: 79.21
+	Hs
		442794 HCK_HUMAN (120-215): 1.21e-12: 68.1: 19.39		DYN2_HUMAN (1-869): 0: 1041: 79.21
+	Hs
		840702 ITSN1_HUMAN (137-216): 1.36e-12: 68.1: 25.00		DYN2_HUMAN (1-869): 0: 1041: 79.21
+	Ce
		220206 SRC2_CAEEL (118-215): 1.65e-14: 73.4: 22.00		DYN1_CAEEL (3-815): 0: 947: 62.09
+	Ce
		666206 SEM5_CAEEL (3-69): 6.24e-14: 70: 28.36		DYN1_CAEEL (3-815): 0: 947: 62.09