HitPredict

Interactor 1: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Interactor 2: GAB2 (Q9UQC2)
GRB2-associated-binding protein 2 (GRB2-associated binder 2) (Growth factor receptor bound protein 2-associated protein 2) (pp100)
Gene: GAB2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.98 1.00 0.991

The method score is based on:

Property Details
Experiments 16371368, 32296183, 31980649, 11782427, 25416956, 28514442, 15143164, 10913131, 9660791, 33961781, 10391903, 20936779, 19380743, 21706016, 19523899, 11027663, 31515488, unassigned1304, unassigned2173, 19172738 and 1 others

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Identification Methods affinity chromatography technology, two hybrid, pull down, x-ray crystallography, isothermal titration calorimetry, peptide array, anti tag coimmunoprecipitation, two hybrid prey pooling approach, two hybrid array, validated two hybrid and 3 others

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Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains PH~SH3_1
Common GO terms GO:0005068 - transmembrane receptor protein tyrosine kinase adaptor activity
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0005886 - plasma membrane
GO:0007165 - signal transduction
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 217
Hs

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Last updated: 15 Jul 2024