HitPredict

Interactor 1: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Interactor 2: SH2B3 (Q9UQQ2)
SH2B adapter protein 3 (Lymphocyte adapter protein) (Lymphocyte-specific adapter protein Lnk) (Signal transduction protein Lnk)
Gene: SH2B3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	8649391
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	SH2~SH2, SH2~SH3_1
Common GO terms	GO:0005068 - transmembrane receptor protein tyrosine kinase adaptor activity GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 217 Hs			1 575
+	Mm
		1141166 GRB2_MOUSE (1-217): 2.48e-76: 230: 99.54		SH2B2_MOUSE (1-573): 7.5e-130: 395: 30.39
+	Hs
		145977 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		SH2B2_HUMAN (25-573): 1.06e-116: 361: 31.30
+	Hs
		855781 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		VAV2_HUMAN (217-544): 2.36e-56: 205: 11.77
+	Mm
		1141129 GRB2_MOUSE (1-217): 2.48e-76: 230: 99.54		VAV2_MOUSE (217-544): 1.87e-55: 202: 12.64
+	Hs
		548677 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		VAV_HUMAN (192-573): 3.94e-49: 184: 11.77
+	Hs
		522887 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		SRC_HUMAN (204-539): 3.8e-47: 174: 13.12
+	Mm
		654982 GRB2_MOUSE (1-217): 2.48e-76: 230: 99.54		VAV_MOUSE (192-573): 4.75e-44: 169: 11.00
+	Hs
		924447 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		GRB2_HUMAN (307-547): 8.13e-46: 162: 12.86
+	Hs
		802818 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		CRKL_HUMAN (364-541): 1.25e-41: 154: 22.35
+	Rn
		924995 GRB2_RAT (1-217): 6.71e-76: 229: 100.00		SHC1_RAT (248-462): 3.21e-40: 154: 21.85
+	Hs
		557655 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		NCK1_HUMAN (286-446): 2.61e-38: 147: 18.39
+	Hs
		782767 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		CSK_HUMAN (354-444): 2.06e-32: 131: 29.67
+	Hs
		924476 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		SHC2_HUMAN (290-469): 3.78e-31: 129: 24.47
+	Mm
		957235 GRB2_MOUSE (1-217): 2.48e-76: 230: 99.54		SHC1_MOUSE (308-453): 3.05e-30: 126: 26.71
+	Hs
		666057 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		SHC1_HUMAN (350-453): 1.1e-29: 125: 34.62
+	Hs
		796538 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		KSYK_HUMAN (363-573): 4.78e-25: 111: 15.57
+	Mm
		1141132 GRB2_MOUSE (1-217): 2.48e-76: 230: 99.54		PLCG1_MOUSE (348-556): 4.56e-20: 97: 17.86
+	Rn
		499159 GRB2_RAT (1-217): 6.71e-76: 229: 100.00		PLCG1_RAT (348-539): 3.09e-20: 97.4: 17.39
+	Hs
		580972 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		PLCG1_HUMAN (348-575): 7.81e-20: 96.2: 14.96
+	Hs
		129269 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		P85B_HUMAN (329-463): 2.73e-18: 90.9: 18.38