HitPredict

Interactor 1: GRB2 (P62994)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Interactor 2: WIPF1 (Q6IN36)
WAS/WASL-interacting protein family member 1 (Wiskott-Aldrich syndrome protein-interacting protein) (WASP-interacting protein)
Gene: WIPF1

Species: Rattus norvegicus

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	16990791
Identification Methods	anti bait coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0017124 - SH3 domain binding GO:0030036 - actin cytoskeleton organization
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 217 Rn			1 487
+	Hs
		554292 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		MUC1_HUMAN (9-479): 5.07e-30: 126: 12.03
+	Hs
		206685 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		WIPF1_HUMAN (1-487): 3.26e-25: 110: 79.32
+	Hs
		924724 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		WIPF2_HUMAN (14-487): 5.23e-24: 106: 36.35
+	Hs
		203218 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		SYNJ1_HUMAN (134-486): 2.91e-11: 68.3: 15.97
+	Hs
		924760 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		PRG4_HUMAN (2-479): 5.21e-11: 67.5: 11.84
+	Hs
		411582 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		MUC1_HUMAN (9-479): 5.07e-30: 126: 12.03
+	Mm
		1225105 NCK1_MOUSE (5-145): 8.99e-23: 96.3: 33.14		WIPF1_MOUSE (1-487): 1.2e-30: 126: 92.70
+	Hs
		337335 ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46		MUC1_HUMAN (9-479): 5.07e-30: 126: 12.03
+	Hs
		279830 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		TRIO_HUMAN (135-356): 8.84e-12: 70.1: 20.26
+	Hs
		206680 NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14		WIPF1_HUMAN (1-487): 3.26e-25: 110: 79.32
+	Hs
		203198 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		SYNJ1_HUMAN (134-486): 2.91e-11: 68.3: 15.97
+	Hs
		557748 NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14		WIPF2_HUMAN (14-487): 5.23e-24: 106: 36.35
+	Hs
		206699 ITSN2_HUMAN (2-61): 5.91e-15: 75: 36.67		WIPF1_HUMAN (1-487): 3.26e-25: 110: 79.32
+	Hs
		206676 FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58		WIPF1_HUMAN (1-487): 3.26e-25: 110: 79.32
+	Hs
		1257321 ITSN2_HUMAN (2-61): 5.91e-15: 75: 36.67		WIPF2_HUMAN (14-487): 5.23e-24: 106: 36.35
+	Hs
		206677 HCK_HUMAN (120-215): 1.21e-12: 68.1: 19.39		WIPF1_HUMAN (1-487): 3.26e-25: 110: 79.32
+	Hs
		203208 NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14		SYNJ1_HUMAN (134-486): 2.91e-11: 68.3: 15.97
+	Mm
		101430 CSK_MOUSE (2-139): 1.12e-23: 99.4: 35.57		F8VPR5_MOUSE (72-474): 4.3e-10: 64.4: 14.11
+	Hs
		279897 ITSN2_HUMAN (2-61): 5.91e-15: 75: 36.67		TRIO_HUMAN (135-356): 8.84e-12: 70.1: 20.26
+	Hs
		412362 FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58		MAGE1_HUMAN (29-379): 2.36e-09: 62.2: 13.65