HitPredict

Interactor 1: TRA2B (P62995)
Transformer-2 protein homolog beta (TRA-2 beta) (TRA2-beta) (hTRA2-beta) (Splicing factor, arginine/serine-rich 10) (Transformer-2 protein homolog B)
Gene: TRA2B

Interactor 2: SRSF3 (P84103)
Serine/arginine-rich splicing factor 3 (Pre-mRNA-splicing factor SRP20) (Splicing factor, arginine/serine-rich 3)
Gene: SRSF3

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.806

Property	Details
Experiments	33961781, 22365833
Identification Methods	affinity chromatography technology, two hybrid, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	RRM_1~RRM_1
Common GO terms	GO:0000398 - mRNA splicing, via spliceosome GO:0003723 - RNA binding GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 288 Hs			1 164
+	Hs
		1040334 TRA2A_HUMAN (1-237): 9.33e-36: 131: 62.06		SRSF7_HUMAN (9-106): 1.02e-30: 112: 67.35
+	Mm
		1161322 TRA2A_MOUSE (1-237): 2.38e-35: 130: 61.18		SRSF7_MOUSE (7-115): 1.47e-26: 102: 60.55
+	Hs
		992758 TRA2A_HUMAN (1-237): 9.33e-36: 131: 62.06		SRSF1_HUMAN (9-80): 1.1e-25: 100: 48.65
+	Hs
		1028644 TRA2A_HUMAN (1-237): 9.33e-36: 131: 62.06		SRSF5_HUMAN (10-112): 2.09e-24: 97: 44.34
+	Hs
		266984 TRA2A_HUMAN (1-237): 9.33e-36: 131: 62.06		SRS10_HUMAN (1-164): 2.25e-24: 96.6: 32.54
+	Hs
		925011 TRA2B_HUMAN (1-267): 9.15e-34: 126: 100.00		SRSF1_HUMAN (9-80): 1.1e-25: 100: 48.65
+	Mm
		925159 TRA2B_MOUSE (1-267): 9.15e-34: 126: 100.00		SRSF3_MOUSE (1-164): 6.39e-27: 100: 100.00
+	Mm
		192621 TRA2B_MOUSE (1-267): 9.15e-34: 126: 100.00		SRSF5_MOUSE (10-112): 1.98e-24: 97: 44.34
+	Hs
		1031314 TRA2A_HUMAN (1-237): 9.33e-36: 131: 62.06		PABP4_HUMAN (5-91): 1.61e-21: 91.9: 26.09
+	Hs
		266958 TRA2B_HUMAN (1-267): 9.15e-34: 126: 100.00		SRS10_HUMAN (1-164): 2.25e-24: 96.6: 32.54
+	Hs
		516502 TRA2A_HUMAN (1-237): 9.33e-36: 131: 62.06		PABP1_HUMAN (1-91): 1.13e-20: 89.6: 25.77
+	Hs
		516451 TRA2B_HUMAN (1-267): 9.15e-34: 126: 100.00		PABP1_HUMAN (1-91): 1.13e-20: 89.6: 25.77
+	Hs
		1028541 TRA2A_HUMAN (1-237): 9.33e-36: 131: 62.06		SRSF9_HUMAN (9-82): 1.91e-19: 83.2: 40.79
+	Mm
		925167 TRA2B_MOUSE (1-267): 9.15e-34: 126: 100.00		SRSF9_MOUSE (9-113): 9.03e-21: 86.6: 37.38
+	Hs
		925020 TRA2B_HUMAN (1-267): 9.15e-34: 126: 100.00		SRSF9_HUMAN (9-82): 1.91e-19: 83.2: 40.79
+	Mm
		857303 TRA2B_MOUSE (1-267): 9.15e-34: 126: 100.00		TIA1_MOUSE (5-107): 1.59e-18: 82.6: 21.70
+	Hs
		993707 TRA2A_HUMAN (1-237): 9.33e-36: 131: 62.06		SRSF4_HUMAN (11-112): 3.43e-16: 76.6: 39.22
+	Hs
		1028895 TRA2A_HUMAN (1-237): 9.33e-36: 131: 62.06		SRSF6_HUMAN (11-88): 3.86e-16: 75.8: 47.44
+	Hs
		925012 TRA2B_HUMAN (1-267): 9.15e-34: 126: 100.00		SRSF4_HUMAN (11-112): 3.43e-16: 76.6: 39.22
+	Hs
		925021 TRA2B_HUMAN (1-267): 9.15e-34: 126: 100.00		SRSF6_HUMAN (11-88): 3.86e-16: 75.8: 47.44