HitPredict

Interactor 1: TRA2B (P62995)
Transformer-2 protein homolog beta (TRA-2 beta) (TRA2-beta) (hTRA2-beta) (Splicing factor, arginine/serine-rich 10) (Transformer-2 protein homolog B)
Gene: TRA2B

Interactor 2: SRSF6 (Q13247)
Serine/arginine-rich splicing factor 6 (Pre-mRNA-splicing factor SRP55) (Splicing factor, arginine/serine-rich 6)
Gene: SRSF6

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.60	1.00	0.775

Property	Details
Experiments	22365833, 24981860
Identification Methods	two hybrid, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	RRM_1~RRM_1
Common GO terms	GO:0000381 - regulation of alternative mRNA splicing, via spliceosome GO:0000398 - mRNA splicing, via spliceosome GO:0003723 - RNA binding GO:0005654 - nucleoplasm GO:0036002 - pre-mRNA binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 288 Hs			1 344
+	Hs
		992758 TRA2A_HUMAN (1-237): 9.33e-36: 131: 62.06		SRSF1_HUMAN (3-188): 3.02e-54: 180: 36.65
+	Hs
		925011 TRA2B_HUMAN (1-267): 9.15e-34: 126: 100.00		SRSF1_HUMAN (3-188): 3.02e-54: 180: 36.65
+	Hs
		1028541 TRA2A_HUMAN (1-237): 9.33e-36: 131: 62.06		SRSF9_HUMAN (3-222): 5.6e-49: 165: 34.22
+	Hs
		993707 TRA2A_HUMAN (1-237): 9.33e-36: 131: 62.06		SRSF4_HUMAN (1-323): 1.85e-45: 163: 63.47
+	Hs
		1314632 RBM22_HUMAN (2-287): 6.71e-33: 126: 15.91		RBM4_HUMAN (1-343): 1.17e-47: 166: 17.05
+	Mm
		925167 TRA2B_MOUSE (1-267): 9.15e-34: 126: 100.00		SRSF9_MOUSE (3-222): 3.56e-49: 166: 35.11
+	Hs
		1028644 TRA2A_HUMAN (1-237): 9.33e-36: 131: 62.06		SRSF5_HUMAN (2-180): 3.02e-46: 160: 64.25
+	Hs
		925020 TRA2B_HUMAN (1-267): 9.15e-34: 126: 100.00		SRSF9_HUMAN (3-222): 5.6e-49: 165: 34.22
+	Hs
		925012 TRA2B_HUMAN (1-267): 9.15e-34: 126: 100.00		SRSF4_HUMAN (1-323): 1.85e-45: 163: 63.47
+	Mm
		192621 TRA2B_MOUSE (1-267): 9.15e-34: 126: 100.00		SRSF5_MOUSE (2-180): 2.78e-46: 160: 64.25
+	Hs
		1028895 TRA2A_HUMAN (1-237): 9.33e-36: 131: 62.06		SRSF6_HUMAN (1-323): 3.2e-43: 154: 100.00
+	Hs
		1029130 RBM22_HUMAN (2-287): 6.71e-33: 126: 15.91		SRSF6_HUMAN (1-323): 3.2e-43: 154: 100.00
+	Hs
		474022 TRA2A_HUMAN (1-237): 9.33e-36: 131: 62.06		PAB4L_HUMAN (1-196): 1.97e-35: 134: 15.94
+	Mm
		857303 TRA2B_MOUSE (1-267): 9.15e-34: 126: 100.00		TIA1_MOUSE (2-335): 1.54e-33: 129: 15.46
+	Hs
		1031314 TRA2A_HUMAN (1-237): 9.33e-36: 131: 62.06		PABP4_HUMAN (101-191): 1.26e-12: 70.7: 21.88
+	Hs
		516502 TRA2A_HUMAN (1-237): 9.33e-36: 131: 62.06		PABP1_HUMAN (101-191): 1.28e-11: 67.6: 19.79
+	Hs
		516451 TRA2B_HUMAN (1-267): 9.15e-34: 126: 100.00		PABP1_HUMAN (101-191): 1.28e-11: 67.6: 19.79
+	Hs
		925003 TRA2B_HUMAN (1-267): 9.15e-34: 126: 100.00		SRSF3_HUMAN (3-78): 2.4e-09: 57.4: 46.84
+	Mm
		925159 TRA2B_MOUSE (1-267): 9.15e-34: 126: 100.00		SRSF3_MOUSE (3-78): 2.4e-09: 57.4: 46.84
+	Hs
		952152 RBM22_HUMAN (2-287): 6.71e-33: 126: 15.91		SRSF3_HUMAN (3-78): 2.4e-09: 57.4: 46.84