HitPredict

Interactor 1: TRA2B (P62995)
Transformer-2 protein homolog beta (TRA-2 beta) (TRA2-beta) (hTRA2-beta) (Splicing factor, arginine/serine-rich 10) (Transformer-2 protein homolog B)
Gene: TRA2B

Interactor 2: RNPS1 (Q15287)
RNA-binding protein with serine-rich domain 1 (SR-related protein LDC2)
Gene: RNPS1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	1.00	0.825

Property	Details
Experiments	17353931, 14729963
Identification Methods	affinity chromatography technology, two hybrid, pull down, anti bait coimmunoprecipitation
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	RRM_1~RRM_1
Common GO terms	GO:0000381 - regulation of alternative mRNA splicing, via spliceosome GO:0000398 - mRNA splicing, via spliceosome GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 288 Hs			1 305
+	Hs
		1070529 Q7Z3L0_HUMAN (32-205): 5.76e-42: 150: 18.99		RNPS1_HUMAN (1-234): 2e-34: 128: 100.00
+	Hs
		1040331 TRA2A_HUMAN (1-237): 9.33e-36: 131: 62.06		RNPS1_HUMAN (1-234): 2e-34: 128: 100.00
+	Hs
		1347098 RBM22_HUMAN (2-287): 6.71e-33: 126: 15.91		PPIE_HUMAN (159-297): 4.41e-33: 125: 17.73
+	Hs
		925150 TRA2B_HUMAN (1-267): 9.15e-34: 126: 100.00		PPIE_HUMAN (159-297): 4.41e-33: 125: 17.73
+	Hs
		642766 ELAV4_HUMAN (52-261): 1.84e-24: 103: 18.40		SART3_HUMAN (2-302): 1.67e-38: 146: 16.32
+	Hs
		199000 RBM22_HUMAN (2-287): 6.71e-33: 126: 15.91		RFOX2_HUMAN (44-274): 2.32e-31: 122: 13.25
+	Hs
		1070694 PPIE_HUMAN (118-201): 7.87e-27: 107: 36.91		RNPS1_HUMAN (1-234): 2e-34: 128: 100.00
+	Hs
		1020261 ELAV2_HUMAN (52-244): 6.85e-24: 101: 20.00		RNPS1_HUMAN (1-234): 2e-34: 128: 100.00
+	Hs
		516502 TRA2A_HUMAN (1-237): 9.33e-36: 131: 62.06		PABP1_HUMAN (65-252): 1.33e-21: 96.9: 16.32
+	Hs
		1020353 ELAV2_HUMAN (52-244): 6.85e-24: 101: 20.00		PPIE_HUMAN (159-297): 4.41e-33: 125: 17.73
+	Hs
		198880 ELAV2_HUMAN (52-244): 6.85e-24: 101: 20.00		RFOX2_HUMAN (44-274): 2.32e-31: 122: 13.25
+	Hs
		516451 TRA2B_HUMAN (1-267): 9.15e-34: 126: 100.00		PABP1_HUMAN (65-252): 1.33e-21: 96.9: 16.32
+	Hs
		1031314 TRA2A_HUMAN (1-237): 9.33e-36: 131: 62.06		PABP4_HUMAN (153-248): 4.98e-19: 89.2: 27.08
+	Hs
		474022 TRA2A_HUMAN (1-237): 9.33e-36: 131: 62.06		PAB4L_HUMAN (161-242): 1.56e-18: 86.5: 30.49
+	Hs
		516744 PPIE_HUMAN (118-201): 7.87e-27: 107: 36.91		PABP1_HUMAN (65-252): 1.33e-21: 96.9: 16.32
+	Hs
		516484 ELAV2_HUMAN (52-244): 6.85e-24: 101: 20.00		PABP1_HUMAN (65-252): 1.33e-21: 96.9: 16.32
+	Ce
		1353617 Q9U2S6_CAEEL (118-203): 1.61e-24: 102: 35.56		Q9U2S6_CAEEL (156-263): 5.51e-20: 90.4: 20.37
+	Hs
		1020249 ELAV2_HUMAN (52-244): 6.85e-24: 101: 20.00		PABP4_HUMAN (153-248): 4.98e-19: 89.2: 27.08
+	Hs
		474019 ELAV2_HUMAN (52-244): 6.85e-24: 101: 20.00		PAB4L_HUMAN (161-242): 1.56e-18: 86.5: 30.49
+	Hs
		474021 PABP4_HUMAN (109-246): 4.69e-22: 97.6: 21.28		PAB4L_HUMAN (161-242): 1.56e-18: 86.5: 30.49