HitPredict

Interactor 1: RAC1 (P63000)
Ras-related C3 botulinum toxin substrate 1 (EC 3.6.5.2) (Cell migration-inducing gene 5 protein) (Ras-like protein TC25) (p21-Rac1)
Gene: RAC1

Interactor 2: PAK2 (Q13177)
Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1) (Gamma-PAK) (PAK65) (S6/H4 kinase) (p21-activated kinase 2) (PAK-2) (p58) [Cleaved into: PAK-2p27 (p27); PAK-2p34 (p34) (C-t-PAK2)]
Gene: PAK2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.93 1.00 0.965

The method score is based on:

Property Details
Experiments 9535855, 31871319, 20936779, 32707033, 20696164, 22705156, 19264842
Identification Methods pull down, affinity chromatography technology, two hybrid, two hybrid pooling approach, solid phase assay
Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains PBD~Ras, Pkinase~Ras
Common GO terms GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0005886 - plasma membrane
GO:0019901 - protein kinase binding
and 3 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 192
Hs

1 524
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024