HitPredict

Interactor 1: RAC1 (P63000)
Ras-related C3 botulinum toxin substrate 1 (EC 3.6.5.2) (Cell migration-inducing gene 5 protein) (Ras-like protein TC25) (p21-Rac1)
Gene: RAC1

Interactor 2: JIP2 (Q13387)
C-Jun-amino-terminal kinase-interacting protein 2 (JIP-2) (JNK-interacting protein 2) (Islet-brain-2) (IB-2) (JNK MAP kinase scaffold protein 2) (Mitogen-activated protein kinase 8-interacting protein 2)
Gene: MAPK8IP2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.44	0.60	0.515

Property	Details
Experiments	32814053
Identification Methods	two hybrid array, two hybrid pooling approach, validated two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0019901 - protein kinase binding GO:0044877 - protein-containing complex binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 192 Hs			1 824
+	Hs
		925491 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		ANS1A_HUMAN (215-809): 4.34e-51: 196: 13.93
+	Hs
		900638 RHOA_HUMAN (5-192): 3.5e-77: 230: 57.98		ANS1B_HUMAN (536-809): 1.38e-53: 204: 15.88
+	Hs
		892522 RAC3_HUMAN (1-191): 2.72e-79: 236: 93.19		ANS1A_HUMAN (215-809): 4.34e-51: 196: 13.93
+	Mm
		892714 RAC3_MOUSE (1-191): 2.72e-79: 236: 93.19		ANS1B_MOUSE (519-809): 2.07e-50: 194: 17.01
+	Hs
		925460 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		SH3R3_HUMAN (136-662): 9.05e-41: 163: 17.23
+	Hs
		925387 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		MICA3_HUMAN (23-631): 7.8e-36: 149: 12.64
+	Hs
		564587 RHOQ_HUMAN (4-187): 4.46e-85: 251: 64.67		MICA3_HUMAN (23-631): 7.8e-36: 149: 12.64
+	Hs
		894241 CDC42_HUMAN (1-192): 1.4e-78: 234: 70.31		SH3R3_HUMAN (136-662): 9.05e-41: 163: 17.23
+	Hs
		1186089 RHOJ_HUMAN (2-189): 1.38e-80: 240: 60.64		MICA3_HUMAN (23-631): 7.8e-36: 149: 12.64
+	Hs
		892450 RAC3_HUMAN (1-191): 2.72e-79: 236: 93.19		MICA3_HUMAN (23-631): 7.8e-36: 149: 12.64
+	Hs
		925396 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		SH3R1_HUMAN (59-663): 1.98e-29: 128: 12.93
+	Ce
		136793 RAC1_CAEEL (1-192): 2.2e-83: 246: 82.81		UNC89_CAEEL (62-418): 6.65e-18: 91.7: 12.43
+	Ce
		104464 G5EBV3_CAEEL (2-192): 6.22e-78: 232: 65.45		UNC89_CAEEL (62-418): 6.65e-18: 91.7: 12.43
+	Hs
		297823 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		K0754_HUMAN (323-706): 2.33e-11: 70.2: 13.77
+	Ce
		136794 CDC42_CAEEL (1-192): 5.89e-76: 227: 69.27		UNC89_CAEEL (62-418): 6.65e-18: 91.7: 12.43
+	Hs
		297812 RAC2_HUMAN (1-192): 1.2e-82: 244: 92.19		K0754_HUMAN (323-706): 2.33e-11: 70.2: 13.77
+	Hs
		297840 RHOJ_HUMAN (2-189): 1.38e-80: 240: 60.64		K0754_HUMAN (323-706): 2.33e-11: 70.2: 13.77
+	Hs
		297819 RAC3_HUMAN (1-191): 2.72e-79: 236: 93.19		K0754_HUMAN (323-706): 2.33e-11: 70.2: 13.77
+	Hs
		297827 RHOG_HUMAN (1-192): 3.1e-79: 236: 71.35		K0754_HUMAN (323-706): 2.33e-11: 70.2: 13.77
+	Hs
		297820 RHOA_HUMAN (5-192): 3.5e-77: 230: 57.98		K0754_HUMAN (323-706): 2.33e-11: 70.2: 13.77